In vitro corticosteroid: Correlation response with primary open-angle glaucoma and ocular corticosteroid sensitivity

John F. Bigger, Paul F. Palmberg, Harry A. Zink

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalAmerican journal of ophthalmology
Volume79
Issue number1
DOIs
StatePublished - Jan 1975
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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