Abstract
The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma.
| Original language | English |
|---|---|
| Pages (from-to) | 92-97 |
| Number of pages | 6 |
| Journal | American Journal of Ophthalmology |
| Volume | 79 |
| Issue number | 1 |
| State | Published - Jan 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
In vitro corticosteroid : Correlation response with primary open-angle glaucoma and ocular corticosteroid sensitivity. / Bigger, John F.; Palmberg, Paul; Zink, Harry A.
In: American Journal of Ophthalmology, Vol. 79, No. 1, 01.01.1975, p. 92-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro corticosteroid
T2 - Correlation response with primary open-angle glaucoma and ocular corticosteroid sensitivity
AU - Bigger, John F.
AU - Palmberg, Paul
AU - Zink, Harry A.
PY - 1975/1/1
Y1 - 1975/1/1
N2 - The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma.
AB - The transformation of human peripheral blood lymphocytes can be inhibited by corticosteroid compounds. In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. A high correlation exists between the level of corticosteroid sensitivity in the lymphocyte and in the eye. In vitro cellular systems may be useful in evaluating the molecular basis of the variability in corticosteroid response, and in understanding the pathogenesis of corticosteroid-induced ocular hypertension and primary open-angle glaucoma.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016438173&partnerID=8YFLogxK
M3 - Article
C2 - 1110208
AN - SCOPUS:0016438173
VL - 79
SP - 92
EP - 97
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 1
ER -