In-vitro and In-vivo nuclear magnetic resonance imaging and spectroscopy of a bioartificial pancreas

Ioannis Constantinidis, Cherie Stabler, Samuel Grant, Nicholas Simpson, Steve Blackband, Robert Long, Athanassios Sambanis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The in-vitro and in-vivo Nuclear Magnetic Resonance (NMR) Imaging and spectroscopy to non-invasively monitor the viability and function of a bioartificial pancreas was described. All in vitro data were obtained from single beads with very high resolution, which allowed the experts to visualize the reorganization of cells with time in culture. For the in vivo studies, a retrievable design consisting of alginate/poly-L-lysine/alginate (APA) beads contained in an agarose gel was used. It was shown that the application of these NMR techniques is very useful in visualizing cell growth within the beads as well as monitoring aspects of intracellular metabolic activity that correlates with cell viability.

Original languageEnglish
Title of host publicationThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
StatePublished - Dec 1 2002
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: Oct 13 2002Oct 16 2002

Other

OtherThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
CountryUnited States
CityAtlanta, GA
Period10/13/0210/16/02

ASJC Scopus subject areas

  • Engineering(all)

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    Constantinidis, I., Stabler, C., Grant, S., Simpson, N., Blackband, S., Long, R., & Sambanis, A. (2002). In-vitro and In-vivo nuclear magnetic resonance imaging and spectroscopy of a bioartificial pancreas. In Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products [MS-3]