In-vitro and In-vivo nuclear magnetic resonance imaging and spectroscopy of a bioartificial pancreas

Ioannis Constantinidis; Cherie Stabler; Samuel Grant; Nicholas Simpson; Steve Blackband; Robert Long; Athanassios Sambanis

In-vitro and In-vivo nuclear magnetic resonance imaging and spectroscopy of a bioartificial pancreas

Ioannis Constantinidis, Cherie Stabler, Samuel Grant, Nicholas Simpson, Steve Blackband, Robert Long, Athanassios Sambanis

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The in-vitro and in-vivo Nuclear Magnetic Resonance (NMR) Imaging and spectroscopy to non-invasively monitor the viability and function of a bioartificial pancreas was described. All in vitro data were obtained from single beads with very high resolution, which allowed the experts to visualize the reorganization of cells with time in culture. For the in vivo studies, a retrievable design consisting of alginate/poly-L-lysine/alginate (APA) beads contained in an agarose gel was used. It was shown that the application of these NMR techniques is very useful in visualizing cell growth within the beads as well as monitoring aspects of intracellular metabolic activity that correlates with cell viability.

Original language	English
Title of host publication	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
State	Published - Dec 1 2002
Event	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States Duration: Oct 13 2002 → Oct 16 2002

Other

Other	Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country	United States
City	Atlanta, GA
Period	10/13/02 → 10/16/02

ASJC Scopus subject areas

Engineering(all)

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In-vitro and In-vivo nuclear magnetic resonance imaging and spectroscopy of a bioartificial pancreas. / Constantinidis, Ioannis; Stabler, Cherie; Grant, Samuel; Simpson, Nicholas; Blackband, Steve; Long, Robert; Sambanis, Athanassios.

Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products. 2002. MS-3.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Constantinidis, I, Stabler, C, Grant, S, Simpson, N, Blackband, S, Long, R & Sambanis, A 2002, In-vitro and In-vivo nuclear magnetic resonance imaging and spectroscopy of a bioartificial pancreas. in Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products., MS-3, Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, Atlanta, GA, United States, 10/13/02.

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AU - Grant, Samuel

AU - Simpson, Nicholas

AU - Blackband, Steve

AU - Long, Robert

AU - Sambanis, Athanassios

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