In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer

H. B. Niell, H. G. Herrod, A. F. Blatnik, M. S. Soloway

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The activity of cis-diamminedichloroplatinum(II) was compared to two second generation platinum analogs, cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) and cis-dichloro-transdihydroxybisisopropylamine platinum(IV) in the N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor model and a tumor colony assay. Murine drug testing revealed that all three drugs were active against the MBT-2 tumor line, although cis-diamminedichloroplatinum(II) was more active than its analogs. All drugs produced enhanced inhibition of clonal growth with increasing drug exposure times. Cis-diamminedichloroplatinum(II) was more active against MBT-2 cells in the plateau growth phase versus the log growth phase after a one hour drug exposure. Similar differential activity depending upon the proliferative state of MBT-2 was not seen with the two platinum analogs. These two platinum analogs have somewhat less activity in vivo and in vitro than cis-diamminedichloroplatinum(II) and would be predicted to be less effective clinically in human bladder cancer than the parent compound.

Original languageEnglish
Pages (from-to)399-402
Number of pages4
JournalJournal of Urology
Volume134
Issue number2
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Platinum
Urinary Bladder Neoplasms
Cisplatin
Pharmaceutical Preparations
Growth
Neoplasms
In Vitro Techniques

ASJC Scopus subject areas

  • Urology

Cite this

Niell, H. B., Herrod, H. G., Blatnik, A. F., & Soloway, M. S. (1985). In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer. Journal of Urology, 134(2), 399-402.

In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer. / Niell, H. B.; Herrod, H. G.; Blatnik, A. F.; Soloway, M. S.

In: Journal of Urology, Vol. 134, No. 2, 01.01.1985, p. 399-402.

Research output: Contribution to journalArticle

Niell, HB, Herrod, HG, Blatnik, AF & Soloway, MS 1985, 'In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer', Journal of Urology, vol. 134, no. 2, pp. 399-402.
Niell, H. B. ; Herrod, H. G. ; Blatnik, A. F. ; Soloway, M. S. / In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer. In: Journal of Urology. 1985 ; Vol. 134, No. 2. pp. 399-402.
@article{d8ac4bb42ab9424c970ee204ab0f905e,
title = "In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer",
abstract = "The activity of cis-diamminedichloroplatinum(II) was compared to two second generation platinum analogs, cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) and cis-dichloro-transdihydroxybisisopropylamine platinum(IV) in the N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor model and a tumor colony assay. Murine drug testing revealed that all three drugs were active against the MBT-2 tumor line, although cis-diamminedichloroplatinum(II) was more active than its analogs. All drugs produced enhanced inhibition of clonal growth with increasing drug exposure times. Cis-diamminedichloroplatinum(II) was more active against MBT-2 cells in the plateau growth phase versus the log growth phase after a one hour drug exposure. Similar differential activity depending upon the proliferative state of MBT-2 was not seen with the two platinum analogs. These two platinum analogs have somewhat less activity in vivo and in vitro than cis-diamminedichloroplatinum(II) and would be predicted to be less effective clinically in human bladder cancer than the parent compound.",
author = "Niell, {H. B.} and Herrod, {H. G.} and Blatnik, {A. F.} and Soloway, {M. S.}",
year = "1985",
month = "1",
day = "1",
language = "English",
volume = "134",
pages = "399--402",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer

AU - Niell, H. B.

AU - Herrod, H. G.

AU - Blatnik, A. F.

AU - Soloway, M. S.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The activity of cis-diamminedichloroplatinum(II) was compared to two second generation platinum analogs, cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) and cis-dichloro-transdihydroxybisisopropylamine platinum(IV) in the N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor model and a tumor colony assay. Murine drug testing revealed that all three drugs were active against the MBT-2 tumor line, although cis-diamminedichloroplatinum(II) was more active than its analogs. All drugs produced enhanced inhibition of clonal growth with increasing drug exposure times. Cis-diamminedichloroplatinum(II) was more active against MBT-2 cells in the plateau growth phase versus the log growth phase after a one hour drug exposure. Similar differential activity depending upon the proliferative state of MBT-2 was not seen with the two platinum analogs. These two platinum analogs have somewhat less activity in vivo and in vitro than cis-diamminedichloroplatinum(II) and would be predicted to be less effective clinically in human bladder cancer than the parent compound.

AB - The activity of cis-diamminedichloroplatinum(II) was compared to two second generation platinum analogs, cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) and cis-dichloro-transdihydroxybisisopropylamine platinum(IV) in the N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor model and a tumor colony assay. Murine drug testing revealed that all three drugs were active against the MBT-2 tumor line, although cis-diamminedichloroplatinum(II) was more active than its analogs. All drugs produced enhanced inhibition of clonal growth with increasing drug exposure times. Cis-diamminedichloroplatinum(II) was more active against MBT-2 cells in the plateau growth phase versus the log growth phase after a one hour drug exposure. Similar differential activity depending upon the proliferative state of MBT-2 was not seen with the two platinum analogs. These two platinum analogs have somewhat less activity in vivo and in vitro than cis-diamminedichloroplatinum(II) and would be predicted to be less effective clinically in human bladder cancer than the parent compound.

UR - http://www.scopus.com/inward/record.url?scp=0021863857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021863857&partnerID=8YFLogxK

M3 - Article

C2 - 3894702

AN - SCOPUS:0021863857

VL - 134

SP - 399

EP - 402

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -