In vitro and in vivo activity of two second generation platinum analogs in murine bladder cancer

H. B. Niell, H. G. Herrod, A. F. Blatnik, M. S. Soloway

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2 Scopus citations

Abstract

The activity of cis-diamminedichloroplatinum(II) was compared to two second generation platinum analogs, cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) and cis-dichloro-transdihydroxybisisopropylamine platinum(IV) in the N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor model and a tumor colony assay. Murine drug testing revealed that all three drugs were active against the MBT-2 tumor line, although cis-diamminedichloroplatinum(II) was more active than its analogs. All drugs produced enhanced inhibition of clonal growth with increasing drug exposure times. Cis-diamminedichloroplatinum(II) was more active against MBT-2 cells in the plateau growth phase versus the log growth phase after a one hour drug exposure. Similar differential activity depending upon the proliferative state of MBT-2 was not seen with the two platinum analogs. These two platinum analogs have somewhat less activity in vivo and in vitro than cis-diamminedichloroplatinum(II) and would be predicted to be less effective clinically in human bladder cancer than the parent compound.

Original languageEnglish (US)
Pages (from-to)399-402
Number of pages4
JournalJournal of Urology
Volume134
Issue number2
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Urology

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