In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome

Rubén A. Quintero, Ramen H. Chmait, Jane Carver, Patricia W. Bornick, Mary H. Allen, Eftichia V. Kontopoulos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The purpose of this study was to assess fetal tissue venous oxygenation (StO2%) in utero during laser therapy for twin-twin transfusion syndrome via visible light spectroscopy (VLS). Study Design: StO2% was measured in 10 donor and recipient twins at the level of the skin and placenta before and after laser therapy (SLPCV). Results: Pre-SLPCV skin StO2% was significantly lower in the donor than in the recipient twin (21.6 ± 6.2 vs 31.2 ± 8.6, respectively; P = .01), but the difference disappeared after SLPCV. Placental surface StO2% measurements in 5 patients showed a significant increase in StO2% in the territory of the recipient (P = .04). Preoperative linear streaming as evidence of nonadmixing deoxygenated and oxygenated blood disappeared after SLPCV. Conclusion: In utero StO2% measurement is possible with VLS. Donor twins can have significantly less StO2% than recipient twins, but this is corrected after SLPCV. Further studies are warranted to determine the value of in utero VLS oximetry.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number6
DOIs
StatePublished - Dec 1 2008

Fingerprint

Fetofetal Transfusion
Oximetry
Spectrum Analysis
Light
Tissue Donors
Laser Therapy
Skin
Placenta
Fetus

Keywords

  • fetus
  • operative fetoscopy
  • oximetry
  • oxygen saturation
  • twin
  • twin-twin transfusion syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome. / Quintero, Rubén A.; Chmait, Ramen H.; Carver, Jane; Bornick, Patricia W.; Allen, Mary H.; Kontopoulos, Eftichia V.

In: American Journal of Obstetrics and Gynecology, Vol. 199, No. 6, 01.12.2008.

Research output: Contribution to journalArticle

Quintero, Rubén A. ; Chmait, Ramen H. ; Carver, Jane ; Bornick, Patricia W. ; Allen, Mary H. ; Kontopoulos, Eftichia V. / In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 199, No. 6.
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