In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome

Rubén A. Quintero, Ramen H. Chmait, Jane Carver, Patricia W. Bornick, Mary H. Allen, Eftichia V. Kontopoulos

Research output: Contribution to journalArticle

6 Scopus citations


Objective: The purpose of this study was to assess fetal tissue venous oxygenation (StO2%) in utero during laser therapy for twin-twin transfusion syndrome via visible light spectroscopy (VLS). Study Design: StO2% was measured in 10 donor and recipient twins at the level of the skin and placenta before and after laser therapy (SLPCV). Results: Pre-SLPCV skin StO2% was significantly lower in the donor than in the recipient twin (21.6 ± 6.2 vs 31.2 ± 8.6, respectively; P = .01), but the difference disappeared after SLPCV. Placental surface StO2% measurements in 5 patients showed a significant increase in StO2% in the territory of the recipient (P = .04). Preoperative linear streaming as evidence of nonadmixing deoxygenated and oxygenated blood disappeared after SLPCV. Conclusion: In utero StO2% measurement is possible with VLS. Donor twins can have significantly less StO2% than recipient twins, but this is corrected after SLPCV. Further studies are warranted to determine the value of in utero VLS oximetry.

Original languageEnglish (US)
Pages (from-to)636.e1-636.e4
JournalAmerican journal of obstetrics and gynecology
Issue number6
StatePublished - Dec 2008



  • fetus
  • operative fetoscopy
  • oximetry
  • oxygen saturation
  • twin
  • twin-twin transfusion syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Quintero, R. A., Chmait, R. H., Carver, J., Bornick, P. W., Allen, M. H., & Kontopoulos, E. V. (2008). In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome. American journal of obstetrics and gynecology, 199(6), 636.e1-636.e4.