In utero endoscopic treatment of posterior urethral valves: Preliminary experience

R. A. Quintero, M. P. Johnson, H. Muñoz, R. Gonzalez, L. Acosta, F. Guevara-Zuloaga, F. Arias, C. Carreño, M. I. Evans

Research output: Contribution to journalArticle

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Abstract

Fetal cystoscopy was performed in nine fetuses with sonographic evidence of lower urinary tract obstruction and normal urinary electrolytes. Posterior urethral valves (PUV) were thought to be present in all cases. Endoscopic fulguration of the valves was performed with YAG-laser energy or electrosurgery using an operating 2.4-mm endoscope. Urethral patency was documented with vesicoinfusion and color Doppler by noting passage of fluid from the fetal bladder into the amniotic cavity. A vesicoamniotic shunt was not typically placed at this setting. Three of nine cases did not have PUV: one fetus had urethral atresia, another had ambiguous genitalia and the third had anal atresia, rectovesical fistula and anterior obstruction. Six of nine cases were confirmed postnatally to have had PUV and urethral patency was documented in four of these six cases (66%). The amniotic fluid volume recovered spontaneously in three of these four cases and was maintained postoperatively. The urethra was not clinically patent in the remaining two cases, but pathological confirmation could not be obtained. Three of nine fetuses survived the neonatal period: two with PUV and the one with urethral atresia. All three babies died of unrelated complications. Two of nine fetuses had failed a pre-cystoscopy shunt. A post-cystoscopy shunt also failed in an additional fetus. While there are no long-term survivors in this series, our early experience shows that urethral patency can be achieved in utero with preservation of renal function and pulmonary development. Further experience is required to improve the diagnosis of PUV and to develop a better technique for eliminating the obstruction.

Original languageEnglish
Pages (from-to)208-216
Number of pages9
JournalPrenatal and Neonatal Medicine
Volume3
Issue number2
StatePublished - Apr 1 1998

Fingerprint

Fetus
Cystoscopy
Electrosurgery
Imperforate Anus
Therapeutics
Disorders of Sex Development
Endoscopes
Solid-State Lasers
Urethra
Amniotic Fluid
Urinary Tract
Electrolytes
Fistula
Survivors
Urinary Bladder
Color
Kidney
Lung

Keywords

  • Congenital anomalies
  • Fetal cystoscopy
  • Fetal obstructive uropathy
  • Fetal therapy
  • Fetoscopy
  • Posterior urethral valves
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Quintero, R. A., Johnson, M. P., Muñoz, H., Gonzalez, R., Acosta, L., Guevara-Zuloaga, F., ... Evans, M. I. (1998). In utero endoscopic treatment of posterior urethral valves: Preliminary experience. Prenatal and Neonatal Medicine, 3(2), 208-216.

In utero endoscopic treatment of posterior urethral valves : Preliminary experience. / Quintero, R. A.; Johnson, M. P.; Muñoz, H.; Gonzalez, R.; Acosta, L.; Guevara-Zuloaga, F.; Arias, F.; Carreño, C.; Evans, M. I.

In: Prenatal and Neonatal Medicine, Vol. 3, No. 2, 01.04.1998, p. 208-216.

Research output: Contribution to journalArticle

Quintero, RA, Johnson, MP, Muñoz, H, Gonzalez, R, Acosta, L, Guevara-Zuloaga, F, Arias, F, Carreño, C & Evans, MI 1998, 'In utero endoscopic treatment of posterior urethral valves: Preliminary experience', Prenatal and Neonatal Medicine, vol. 3, no. 2, pp. 208-216.
Quintero RA, Johnson MP, Muñoz H, Gonzalez R, Acosta L, Guevara-Zuloaga F et al. In utero endoscopic treatment of posterior urethral valves: Preliminary experience. Prenatal and Neonatal Medicine. 1998 Apr 1;3(2):208-216.
Quintero, R. A. ; Johnson, M. P. ; Muñoz, H. ; Gonzalez, R. ; Acosta, L. ; Guevara-Zuloaga, F. ; Arias, F. ; Carreño, C. ; Evans, M. I. / In utero endoscopic treatment of posterior urethral valves : Preliminary experience. In: Prenatal and Neonatal Medicine. 1998 ; Vol. 3, No. 2. pp. 208-216.
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