In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Kari C. Nadeau; Zhigang Li; Shohreh Farzan; Devin Koestler; David Robbins; Dennis Liang Fei; Meena Malipatlolla; Holden Maecker; Richard Enelow; Susan Korrick; Margaret R. Karagas

doi:10.1016/j.clim.2014.09.004

In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Kari C. Nadeau, Zhigang Li, Shohreh Farzan, Devin Koestler, David Robbins, Dennis Liang Fei, Meena Malipatlolla, Holden Maecker, Richard Enelow, Susan Korrick, Margaret R. Karagas

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52 Scopus citations

Abstract

Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.

Original language	English (US)
Pages (from-to)	188-197
Number of pages	10
Journal	Clinical Immunology
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2014.09.004
State	Published - Dec 1 2014

Keywords

AQP9
Arsenic
IL1β
Immune function
In utero
T cell

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. / Nadeau, Kari C.; Li, Zhigang; Farzan, Shohreh; Koestler, Devin; Robbins, David; Fei, Dennis Liang; Malipatlolla, Meena; Maecker, Holden; Enelow, Richard; Korrick, Susan; Karagas, Margaret R.

In: Clinical Immunology, Vol. 155, No. 2, 01.12.2014, p. 188-197.

Research output: Contribution to journal › Article › peer-review

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title = "In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort",

abstract = "Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.",

keywords = "AQP9, Arsenic, IL1β, Immune function, In utero, T cell",

author = "Nadeau, {Kari C.} and Zhigang Li and Shohreh Farzan and Devin Koestler and David Robbins and Fei, {Dennis Liang} and Meena Malipatlolla and Holden Maecker and Richard Enelow and Susan Korrick and Karagas, {Margaret R.}",

note = "Funding Information: This work was supported by grants P01 ES022832 and R21 ES020936 from the National Institute of Environmental Health Sciences (NIEHS), US National Institutes of Health (NIH); and RD-83459901 from the US Environmental Protection Agency (EPA). No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Li, Zhigang

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AU - Robbins, David

AU - Fei, Dennis Liang

AU - Malipatlolla, Meena

AU - Maecker, Holden

AU - Enelow, Richard

AU - Korrick, Susan

AU - Karagas, Margaret R.

N1 - Funding Information: This work was supported by grants P01 ES022832 and R21 ES020936 from the National Institute of Environmental Health Sciences (NIEHS), US National Institutes of Health (NIH); and RD-83459901 from the US Environmental Protection Agency (EPA). No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2014 Elsevier Inc. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.

AB - Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.

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In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Abstract

Keywords

ASJC Scopus subject areas

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