In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Kari C. Nadeau, Zhigang Li, Shohreh Farzan, Devin Koestler, David J Robbins, Dennis Liang Fei, Meena Malipatlolla, Holden Maecker, Richard Enelow, Susan Korrick, Margaret R. Karagas

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.

Original languageEnglish
Pages (from-to)188-197
Number of pages10
JournalClinical Immunology
Volume155
Issue number2
DOIs
StatePublished - Dec 1 2014

Fingerprint

Arsenic
Pregnancy
Cell Count
T-Lymphocytes
Environmental Exposure
Fetal Blood
Interleukin-2
Immune System
Mothers
Cytokines
Health
Genes

Keywords

  • AQP9
  • Arsenic
  • IL1β
  • Immune function
  • In utero
  • T cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Nadeau, K. C., Li, Z., Farzan, S., Koestler, D., Robbins, D. J., Fei, D. L., ... Karagas, M. R. (2014). In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. Clinical Immunology, 155(2), 188-197. https://doi.org/10.1016/j.clim.2014.09.004

In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. / Nadeau, Kari C.; Li, Zhigang; Farzan, Shohreh; Koestler, Devin; Robbins, David J; Fei, Dennis Liang; Malipatlolla, Meena; Maecker, Holden; Enelow, Richard; Korrick, Susan; Karagas, Margaret R.

In: Clinical Immunology, Vol. 155, No. 2, 01.12.2014, p. 188-197.

Research output: Contribution to journalArticle

Nadeau, KC, Li, Z, Farzan, S, Koestler, D, Robbins, DJ, Fei, DL, Malipatlolla, M, Maecker, H, Enelow, R, Korrick, S & Karagas, MR 2014, 'In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort', Clinical Immunology, vol. 155, no. 2, pp. 188-197. https://doi.org/10.1016/j.clim.2014.09.004
Nadeau, Kari C. ; Li, Zhigang ; Farzan, Shohreh ; Koestler, Devin ; Robbins, David J ; Fei, Dennis Liang ; Malipatlolla, Meena ; Maecker, Holden ; Enelow, Richard ; Korrick, Susan ; Karagas, Margaret R. / In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. In: Clinical Immunology. 2014 ; Vol. 155, No. 2. pp. 188-197.
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