In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Kari C. Nadeau; Zhigang Li; Shohreh Farzan; Devin Koestler; David Robbins; Dennis Liang Fei; Meena Malipatlolla; Holden Maecker; Richard Enelow; Susan Korrick; Margaret R. Karagas

doi:10.1016/j.clim.2014.09.004

In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

Kari C. Nadeau, Zhigang Li, Shohreh Farzan, Devin Koestler, David Robbins, Dennis Liang Fei, Meena Malipatlolla, Holden Maecker, Richard Enelow, Susan Korrick, Margaret R. Karagas

Surgery

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.

Original language	English (US)
Pages (from-to)	188-197
Number of pages	10
Journal	Clinical Immunology
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2014.09.004
State	Published - Dec 1 2014

Keywords

AQP9
Arsenic
IL1β
Immune function
In utero
T cell

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. / Nadeau, Kari C.; Li, Zhigang; Farzan, Shohreh; Koestler, Devin; Robbins, David; Fei, Dennis Liang; Malipatlolla, Meena; Maecker, Holden; Enelow, Richard; Korrick, Susan; Karagas, Margaret R.

In: Clinical Immunology, Vol. 155, No. 2, 01.12.2014, p. 188-197.

Research output: Contribution to journal › Article › peer-review

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abstract = "Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.",

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author = "Nadeau, {Kari C.} and Zhigang Li and Shohreh Farzan and Devin Koestler and David Robbins and Fei, {Dennis Liang} and Meena Malipatlolla and Holden Maecker and Richard Enelow and Susan Korrick and Karagas, {Margaret R.}",

note = "Funding Information: This work was supported by grants P01 ES022832 and R21 ES020936 from the National Institute of Environmental Health Sciences (NIEHS), US National Institutes of Health (NIH); and RD-83459901 from the US Environmental Protection Agency (EPA). No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ",

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AU - Enelow, Richard

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AU - Karagas, Margaret R.

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N2 - Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.

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