Abstract
Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.
| Original language | English |
|---|---|
| Pages (from-to) | 188-197 |
| Number of pages | 10 |
| Journal | Clinical Immunology |
| Volume | 155 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1 2014 |
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Keywords
- AQP9
- Arsenic
- IL1β
- Immune function
- In utero
- T cell
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. / Nadeau, Kari C.; Li, Zhigang; Farzan, Shohreh; Koestler, Devin; Robbins, David J; Fei, Dennis Liang; Malipatlolla, Meena; Maecker, Holden; Enelow, Richard; Korrick, Susan; Karagas, Margaret R.
In: Clinical Immunology, Vol. 155, No. 2, 01.12.2014, p. 188-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort
AU - Nadeau, Kari C.
AU - Li, Zhigang
AU - Farzan, Shohreh
AU - Koestler, Devin
AU - Robbins, David J
AU - Fei, Dennis Liang
AU - Malipatlolla, Meena
AU - Maecker, Holden
AU - Enelow, Richard
AU - Korrick, Susan
AU - Karagas, Margaret R.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.
AB - Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4. +/CD8. + T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10. μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA. + CD4. + cord blood CD69. + T cell counts (N. = 116, p= 0.04) and positively associated with CD45RA. + CD69. - CD294. + cell counts ( p= 0.01). In placental samples (N. = 70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β ( p= 0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.
KW - AQP9
KW - Arsenic
KW - IL1β
KW - Immune function
KW - In utero
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=84908367013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908367013&partnerID=8YFLogxK
U2 - 10.1016/j.clim.2014.09.004
DO - 10.1016/j.clim.2014.09.004
M3 - Article
C2 - 25229165
AN - SCOPUS:84908367013
VL - 155
SP - 188
EP - 197
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 2
ER -