In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer

Peter J. Milne, Fabrice Manns, David B. Denham, Jean Marie Parel, David S. Robinson

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Temperature increases and the resultant thermal field produced by the irradiation of ex vivo (porcine and human) and in vivo (porcine) tissue models appropriate to the treatment of human breast tissue using Nd:YAG (cw: 60 W) radiation delivered with a interstitial fiber optic probe were recorded with an array of fifteen 23 gauge needle thermocouple probes connected to a laboratory computer based data acquisition system. Using a stepwise decreasing power cycle to avoid tissue charring, acceptably symmetric thermal fields of repeatable volumetric dimensions were obtained. Reproducible thermal gradients and predictable tissue necrosis without carbonization could be induced in a three centimeter diameter region around the fiber probe during a single treatment lasting only 3 minutes. The time-dependence of the temperature rise of the thermocouples surrounding the LITT probe were quantitatively modeled with simple linear functions during the applied laser heating cycles.

Original languageEnglish (US)
Pages (from-to)455-464
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 1999
EventProceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - San Jose, CA, USA
Duration: Jan 23 1999Jan 24 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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