In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer

Peter J. Milne, Fabrice Manns, David B. Denham, Jean-Marie A Parel, David S. Robinson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Temperature increases and the resultant thermal field produced by the irradiation of ex vivo (porcine and human) and in vivo (porcine) tissue models appropriate to the treatment of human breast tissue using Nd:YAG (cw: 60 W) radiation delivered with a interstitial fiber optic probe were recorded with an array of fifteen 23 gauge needle thermocouple probes connected to a laboratory computer based data acquisition system. Using a stepwise decreasing power cycle to avoid tissue charring, acceptably symmetric thermal fields of repeatable volumetric dimensions were obtained. Reproducible thermal gradients and predictable tissue necrosis without carbonization could be induced in a three centimeter diameter region around the fiber probe during a single treatment lasting only 3 minutes. The time-dependence of the temperature rise of the thermocouples surrounding the LITT probe were quantitatively modeled with simple linear functions during the applied laser heating cycles.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages455-464
Number of pages10
Volume3590
StatePublished - 1999
EventProceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - San Jose, CA, USA
Duration: Jan 23 1999Jan 24 1999

Other

OtherProceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX
CitySan Jose, CA, USA
Period1/23/991/24/99

Fingerprint

in situ measurement
breast
interstitials
Temperature distribution
temperature distribution
cancer
Tissue
Lasers
probes
thermocouples
Thermocouples
lasers
charring
Laser heating
cycles
carbonization
necrosis
laser heating
Carbonization
needles

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Milne, P. J., Manns, F., Denham, D. B., Parel, J-M. A., & Robinson, D. S. (1999). In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3590, pp. 455-464). Society of Photo-Optical Instrumentation Engineers.

In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer. / Milne, Peter J.; Manns, Fabrice; Denham, David B.; Parel, Jean-Marie A; Robinson, David S.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3590 Society of Photo-Optical Instrumentation Engineers, 1999. p. 455-464.

Research output: Chapter in Book/Report/Conference proceedingChapter

Milne, PJ, Manns, F, Denham, DB, Parel, J-MA & Robinson, DS 1999, In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3590, Society of Photo-Optical Instrumentation Engineers, pp. 455-464, Proceedings of the 1999 Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, San Jose, CA, USA, 1/23/99.
Milne PJ, Manns F, Denham DB, Parel J-MA, Robinson DS. In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3590. Society of Photo-Optical Instrumentation Engineers. 1999. p. 455-464
Milne, Peter J. ; Manns, Fabrice ; Denham, David B. ; Parel, Jean-Marie A ; Robinson, David S. / In-situ measurement and analysis of the temperature fields in laser interstitial thermotherapy of breast cancer. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3590 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 455-464
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