In situ forming biodegradable biomaterials

Alison B. Pratt, Jeffrey A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A crosslinking scheme for in situ biomaterial formation was described. It was shown that materials made from pegylated acrylates and multi-cysteine peptides can degraded by enzymatic activity. Materials made from pegylated acrylates and cysteine-containing peptides were used to deliver an active morpho-genetic protein, BMP-2, and to induce bone formation in ectopic implants in rats. It was concluded that the crosslinking reaction is highly self-selective and suitable for forming materials in contact with cells and tissues.

Original languageEnglish
Title of host publicationSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
StatePublished - Dec 1 2000
Externally publishedYes
EventSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom
Duration: Jul 16 2000Jul 19 2000

Other

OtherSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
CountryUnited Kingdom
CityYork
Period7/16/007/19/00

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Pratt, A. B., & Hubbell, J. A. (2000). In situ forming biodegradable biomaterials. In Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling