In silico search for the expressed sequences in the region q14.3 of human chromosome 13

T. V. Tyazhelova, Dmitry V Ivanov, S. A. Nazarenko, A. V. Baranova, N. K. Yankovsky

Research output: Contribution to journalArticle

Abstract

Using computer-aided genomic methods, a complete map of the expressed sequence tags (EST) located in the human genome region 13q14.3 between the STS markers, D13S810 and D13S1469, was constructed. A total of 62 EST clusters were formed, of which 12 clusters corresponded to the already known human genes, 4 clusters represented pseudogenes, and 10 clusters were new human genes. The use of the method of reverse transcription in combination with polymerase chain reaction (RT-PCR) provided experimental confirmation of the existence of mRNA transcripts for the novel human genes revealed in silico.

Original languageEnglish
Pages (from-to)422-426
Number of pages5
JournalGenetika
Volume40
Issue number3
StatePublished - Dec 1 2004
Externally publishedYes

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Chromosomes, Human, Pair 13
Human Chromosomes
Computer Simulation
Expressed Sequence Tags
Pseudogenes
Human Genome
Multigene Family
Genes
Reverse Transcription
Polymerase Chain Reaction
Messenger RNA

ASJC Scopus subject areas

  • Genetics

Cite this

Tyazhelova, T. V., Ivanov, D. V., Nazarenko, S. A., Baranova, A. V., & Yankovsky, N. K. (2004). In silico search for the expressed sequences in the region q14.3 of human chromosome 13. Genetika, 40(3), 422-426.

In silico search for the expressed sequences in the region q14.3 of human chromosome 13. / Tyazhelova, T. V.; Ivanov, Dmitry V; Nazarenko, S. A.; Baranova, A. V.; Yankovsky, N. K.

In: Genetika, Vol. 40, No. 3, 01.12.2004, p. 422-426.

Research output: Contribution to journalArticle

Tyazhelova, TV, Ivanov, DV, Nazarenko, SA, Baranova, AV & Yankovsky, NK 2004, 'In silico search for the expressed sequences in the region q14.3 of human chromosome 13', Genetika, vol. 40, no. 3, pp. 422-426.
Tyazhelova TV, Ivanov DV, Nazarenko SA, Baranova AV, Yankovsky NK. In silico search for the expressed sequences in the region q14.3 of human chromosome 13. Genetika. 2004 Dec 1;40(3):422-426.
Tyazhelova, T. V. ; Ivanov, Dmitry V ; Nazarenko, S. A. ; Baranova, A. V. ; Yankovsky, N. K. / In silico search for the expressed sequences in the region q14.3 of human chromosome 13. In: Genetika. 2004 ; Vol. 40, No. 3. pp. 422-426.
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