In silico screening for tumour-specific expressed sequences in human genome

A. V. Baranova, A. V. Lobashev, D. V. Ivanov, L. L. Krukovskaya, N. K. Yankovsky, A. P. Kozlov

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalFEBS letters
Volume508
Issue number1
DOIs
StatePublished - Nov 9 2001
Externally publishedYes

Keywords

  • Cancer
  • Computer-based differential display
  • Gene expression

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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  • Cite this

    Baranova, A. V., Lobashev, A. V., Ivanov, D. V., Krukovskaya, L. L., Yankovsky, N. K., & Kozlov, A. P. (2001). In silico screening for tumour-specific expressed sequences in human genome. FEBS letters, 508(1), 143-148. https://doi.org/10.1016/S0014-5793(01)03028-9