Abstract
A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
Original language | English (US) |
---|---|
Pages (from-to) | 143-148 |
Number of pages | 6 |
Journal | FEBS letters |
Volume | 508 |
Issue number | 1 |
DOIs | |
State | Published - Nov 9 2001 |
Externally published | Yes |
Keywords
- Cancer
- Computer-based differential display
- Gene expression
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology