In silico screening for tumour-specific expressed sequences in human genome

A. V. Baranova; A. V. Lobashev; D. V. Ivanov; L. L. Krukovskaya; N. K. Yankovsky; A. P. Kozlov

doi:10.1016/S0014-5793(01)03028-9

In silico screening for tumour-specific expressed sequences in human genome

A. V. Baranova, A. V. Lobashev, D. V. Ivanov, L. L. Krukovskaya, N. K. Yankovsky, A. P. Kozlov

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.

Original language	English (US)
Pages (from-to)	143-148
Number of pages	6
Journal	FEBS letters
Volume	508
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(01)03028-9
State	Published - Nov 9 2001
Externally published	Yes

Keywords

Cancer
Computer-based differential display
Gene expression

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "In silico screening for tumour-specific expressed sequences in human genome",

abstract = "A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.",

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AU - Lobashev, A. V.

AU - Ivanov, D. V.

AU - Krukovskaya, L. L.

AU - Yankovsky, N. K.

AU - Kozlov, A. P.

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KW - Computer-based differential display

KW - Gene expression

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