Abstract
A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
| Original language | English |
|---|---|
| Pages (from-to) | 143-148 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 508 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 9 2001 |
| Externally published | Yes |
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Keywords
- Cancer
- Computer-based differential display
- Gene expression
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
In silico screening for tumour-specific expressed sequences in human genome. / Baranova, A. V.; Lobashev, A. V.; Ivanov, Dmitry V; Krukovskaya, L. L.; Yankovsky, N. K.; Kozlov, A. P.
In: FEBS Letters, Vol. 508, No. 1, 09.11.2001, p. 143-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In silico screening for tumour-specific expressed sequences in human genome
AU - Baranova, A. V.
AU - Lobashev, A. V.
AU - Ivanov, Dmitry V
AU - Krukovskaya, L. L.
AU - Yankovsky, N. K.
AU - Kozlov, A. P.
PY - 2001/11/9
Y1 - 2001/11/9
N2 - A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
AB - A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
KW - Cancer
KW - Computer-based differential display
KW - Gene expression
UR - http://www.scopus.com/inward/record.url?scp=0035834430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035834430&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(01)03028-9
DO - 10.1016/S0014-5793(01)03028-9
M3 - Article
C2 - 11707285
AN - SCOPUS:0035834430
VL - 508
SP - 143
EP - 148
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -