Abstract
A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-148 |
| Number of pages | 6 |
| Journal | FEBS letters |
| Volume | 508 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 9 2001 |
| Externally published | Yes |
Keywords
- Cancer
- Computer-based differential display
- Gene expression
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Cite this
Baranova, A. V., Lobashev, A. V., Ivanov, D. V., Krukovskaya, L. L., Yankovsky, N. K., & Kozlov, A. P. (2001). In silico screening for tumour-specific expressed sequences in human genome. FEBS letters, 508(1), 143-148. https://doi.org/10.1016/S0014-5793(01)03028-9