In silico screening for tumour-specific expressed sequences in human genome

A. V. Baranova, A. V. Lobashev, Dmitry V Ivanov, L. L. Krukovskaya, N. K. Yankovsky, A. P. Kozlov

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalFEBS Letters
Volume508
Issue number1
DOIs
StatePublished - Nov 9 2001
Externally publishedYes

Fingerprint

Human Genome
Computer Simulation
Tumors
Screening
Genes
Expressed Sequence Tags
Neoplasms
Tissue
Tumor Biomarkers
Gene expression
Multigene Family
Display devices
Gene Expression
Proteins

Keywords

  • Cancer
  • Computer-based differential display
  • Gene expression

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Baranova, A. V., Lobashev, A. V., Ivanov, D. V., Krukovskaya, L. L., Yankovsky, N. K., & Kozlov, A. P. (2001). In silico screening for tumour-specific expressed sequences in human genome. FEBS Letters, 508(1), 143-148. https://doi.org/10.1016/S0014-5793(01)03028-9

In silico screening for tumour-specific expressed sequences in human genome. / Baranova, A. V.; Lobashev, A. V.; Ivanov, Dmitry V; Krukovskaya, L. L.; Yankovsky, N. K.; Kozlov, A. P.

In: FEBS Letters, Vol. 508, No. 1, 09.11.2001, p. 143-148.

Research output: Contribution to journalArticle

Baranova, AV, Lobashev, AV, Ivanov, DV, Krukovskaya, LL, Yankovsky, NK & Kozlov, AP 2001, 'In silico screening for tumour-specific expressed sequences in human genome', FEBS Letters, vol. 508, no. 1, pp. 143-148. https://doi.org/10.1016/S0014-5793(01)03028-9
Baranova AV, Lobashev AV, Ivanov DV, Krukovskaya LL, Yankovsky NK, Kozlov AP. In silico screening for tumour-specific expressed sequences in human genome. FEBS Letters. 2001 Nov 9;508(1):143-148. https://doi.org/10.1016/S0014-5793(01)03028-9
Baranova, A. V. ; Lobashev, A. V. ; Ivanov, Dmitry V ; Krukovskaya, L. L. ; Yankovsky, N. K. ; Kozlov, A. P. / In silico screening for tumour-specific expressed sequences in human genome. In: FEBS Letters. 2001 ; Vol. 508, No. 1. pp. 143-148.
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