Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization

S. Roper, C. P. Ko

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.

Original languageEnglish (US)
Pages (from-to)66-68
Number of pages3
JournalScience
Volume202
Issue number4363
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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