Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization

Stephen D Roper, C. P. Ko

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalScience
Volume202
Issue number4363
StatePublished - Dec 1 1978
Externally publishedYes

Fingerprint

Vagus Nerve
Tetrodotoxin
Denervation
Ganglia
Anura
Parasympathectomy
Neurons
Synapses

ASJC Scopus subject areas

  • General

Cite this

Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization. / Roper, Stephen D; Ko, C. P.

In: Science, Vol. 202, No. 4363, 01.12.1978, p. 66-68.

Research output: Contribution to journalArticle

@article{d20051f46e904e33984104e91d095d72,
title = "Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization",
abstract = "Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.",
author = "Roper, {Stephen D} and Ko, {C. P.}",
year = "1978",
month = "12",
day = "1",
language = "English",
volume = "202",
pages = "66--68",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4363",

}

TY - JOUR

T1 - Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization

AU - Roper, Stephen D

AU - Ko, C. P.

PY - 1978/12/1

Y1 - 1978/12/1

N2 - Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.

AB - Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.

UR - http://www.scopus.com/inward/record.url?scp=0018135297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018135297&partnerID=8YFLogxK

M3 - Article

VL - 202

SP - 66

EP - 68

JO - Science

JF - Science

SN - 0036-8075

IS - 4363

ER -