Improving the blood compatibility of ion-selective electrodes by employing poly(MPC-co-BMA), a copolymer containing phosphorylcholine, as a membrane coating

Maria J. Berrocal, R. Daniel Johnson, Ibrahim H.A. Badr, Mingdong Liu, Dayong Gao, Leonidas G. Bachas

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The hydrogel poly(2-methacryloyloxyethylphosphorylcholine-co-butyl methacrylate), or poly(MPC-co-BMA), was used as a coating for polyurethane- and poly(vinyl chloride)-based membranes to develop ion-selective electrodes (ISEs) with enhanced blood compatibility. Adverse interactions of poly(MPC-co-BMA) with blood were diminished due to the phosphorylcholine functionalities of the hydrogel, which mimic the phospholipid polar groups present on the surface of many cell membranes. As demonstrated by immunostaining, hydrogel-coated PVC membranes soaked in platelet-rich plasma showed less adhesion and activation of platelets than uncoated PVC membranes, indicating an improvement in biocompatibility owing to the hydrogel. Furthermore, little differences in the potentiometric response characteristics, e.g., slope, detection limit, and selectivity, of ISEs employing uncoated and coated membranes were observed.

Original languageEnglish (US)
Pages (from-to)3644-3648
Number of pages5
JournalAnalytical Chemistry
Volume74
Issue number15
DOIs
StatePublished - Aug 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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