Improving resolution of optical coherence tomography for imaging of microstructures

Kai Shen, Hui Lu, James H. Wang, Michael Renxun Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Multi-frame superresolution technique has been used to improve the lateral resolution of spectral domain optical coherence tomography (SD-OCT) for imaging of 3D microstructures. By adjusting the voltages applied to x and y galvanometer scanners in the measurement arm, small lateral imaging positional shifts have been introduced among different C-scans. Utilizing the extracted x-y plane en face image frames from these specially offset C-scan image sets at the same axial position, we have reconstructed the lateral high resolution image by the efficient multi-frame superresolution technique. To further improve the image quality, we applied the latest K-SVD and bilateral total variation denoising algorithms to the raw SD-OCT lateral images before and along with the superresolution processing, respectively. The performance of the SD-OCT of improved lateral resolution is demonstrated by 3D imaging a microstructure fabricated by photolithography and a double-layer microfluidic device.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9334
ISBN (Print)9781628414240
DOIs
StatePublished - 2015
EventOptical Methods in Developmental Biology III - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Other

OtherOptical Methods in Developmental Biology III
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Fingerprint

Optical tomography
Optical Coherence Tomography
tomography
Lab-On-A-Chip Devices
Imaging techniques
microstructure
Microstructure
Galvanometers
Photolithography
Singular value decomposition
Image resolution
Microfluidics
Image quality
galvanometers
microfluidic devices
photolithography
scanners
Electric potential
Processing
adjusting

Keywords

  • Lateral resolution
  • Optical coherence tomography
  • Superresolution

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Shen, K., Lu, H., Wang, J. H., & Wang, M. R. (2015). Improving resolution of optical coherence tomography for imaging of microstructures. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9334). [93340X] SPIE. https://doi.org/10.1117/12.2080415

Improving resolution of optical coherence tomography for imaging of microstructures. / Shen, Kai; Lu, Hui; Wang, James H.; Wang, Michael Renxun.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9334 SPIE, 2015. 93340X.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shen, K, Lu, H, Wang, JH & Wang, MR 2015, Improving resolution of optical coherence tomography for imaging of microstructures. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9334, 93340X, SPIE, Optical Methods in Developmental Biology III, San Francisco, United States, 2/7/15. https://doi.org/10.1117/12.2080415
Shen K, Lu H, Wang JH, Wang MR. Improving resolution of optical coherence tomography for imaging of microstructures. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9334. SPIE. 2015. 93340X https://doi.org/10.1117/12.2080415
Shen, Kai ; Lu, Hui ; Wang, James H. ; Wang, Michael Renxun. / Improving resolution of optical coherence tomography for imaging of microstructures. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9334 SPIE, 2015.
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