Improving resolution of optical coherence tomography for imaging of microstructures

Kai Shen, Hui Lu, James H. Wang, Michael Renxun Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations


Multi-frame superresolution technique has been used to improve the lateral resolution of spectral domain optical coherence tomography (SD-OCT) for imaging of 3D microstructures. By adjusting the voltages applied to x and y galvanometer scanners in the measurement arm, small lateral imaging positional shifts have been introduced among different C-scans. Utilizing the extracted x-y plane en face image frames from these specially offset C-scan image sets at the same axial position, we have reconstructed the lateral high resolution image by the efficient multi-frame superresolution technique. To further improve the image quality, we applied the latest K-SVD and bilateral total variation denoising algorithms to the raw SD-OCT lateral images before and along with the superresolution processing, respectively. The performance of the SD-OCT of improved lateral resolution is demonstrated by 3D imaging a microstructure fabricated by photolithography and a double-layer microfluidic device.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISBN (Print)9781628414240
StatePublished - 2015
EventOptical Methods in Developmental Biology III - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015


OtherOptical Methods in Developmental Biology III
Country/TerritoryUnited States
CitySan Francisco


  • Lateral resolution
  • Optical coherence tomography
  • Superresolution

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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