Abstract
Background. Receiver operating characteristic (ROC) curve analysis provides detailed information about the performance of a diagnostic test. Methods and Results. As part of a multicenter phase III trial, 160 patients with known or suspected coronary artery disease underwent planar stress-rest 99mTc-labeled tetrofosmin and stress-redistribution 201Tl imaging within 14 days of each other, to compare the diagnostic accuracy of these imaging modalities by ROC curve analysis. Coronary arteriography was used as the reference standard and greater than 70% stenosis was considered significant. ROC curve analysis showed improved detection of coronary artery disease with 99mTc-labeled tetrofosmin compared with 201Tl, with ROC curve areas of 0.765 versus 0.644, respectively (p = 0.02), 99mTc-labeled tetrofosmin also better identified single-vessel disease in those without previous myocardial infarction (ROC curve areas of 0.684 vs 0.510 for 99mTc-labeled tetrofosmin and 201Tl, respectively; p = 0.04) and enhanced the detection of multivessel disease in those with previous myocardial infarction (ROC curve areas of 0.764 vs 0.638, respectively; p = 0.02). Conclusions. Detailed assessment of diagnostic performance by ROC curve analysis shows that, for planar imaging, 99mTc-labeled tetrofosmin enhances the detection of coronary artery disease compared with 201Tl.
| Original language | English |
|---|---|
| Pages (from-to) | 291-297 |
| Number of pages | 7 |
| Journal | Journal of Nuclear Cardiology |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 1997 |
| Externally published | Yes |
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Keywords
- Coronary artery disease
- Receiver operating characteristic curve analysis
- Technetium 99m-labeled tetrofosmin
- Thallium-201
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. / Khattar, Rajdeep S.; Hendel, Robert; Crawley, John C W; Wackers, Frans J.; Rigo, Pierre; Zaret, Barry L.; Sridhara, Bangalore S.; Lahiri, Avijit.
In: Journal of Nuclear Cardiology, Vol. 4, No. 4, 01.07.1997, p. 291-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
AU - Khattar, Rajdeep S.
AU - Hendel, Robert
AU - Crawley, John C W
AU - Wackers, Frans J.
AU - Rigo, Pierre
AU - Zaret, Barry L.
AU - Sridhara, Bangalore S.
AU - Lahiri, Avijit
PY - 1997/7/1
Y1 - 1997/7/1
N2 - Background. Receiver operating characteristic (ROC) curve analysis provides detailed information about the performance of a diagnostic test. Methods and Results. As part of a multicenter phase III trial, 160 patients with known or suspected coronary artery disease underwent planar stress-rest 99mTc-labeled tetrofosmin and stress-redistribution 201Tl imaging within 14 days of each other, to compare the diagnostic accuracy of these imaging modalities by ROC curve analysis. Coronary arteriography was used as the reference standard and greater than 70% stenosis was considered significant. ROC curve analysis showed improved detection of coronary artery disease with 99mTc-labeled tetrofosmin compared with 201Tl, with ROC curve areas of 0.765 versus 0.644, respectively (p = 0.02), 99mTc-labeled tetrofosmin also better identified single-vessel disease in those without previous myocardial infarction (ROC curve areas of 0.684 vs 0.510 for 99mTc-labeled tetrofosmin and 201Tl, respectively; p = 0.04) and enhanced the detection of multivessel disease in those with previous myocardial infarction (ROC curve areas of 0.764 vs 0.638, respectively; p = 0.02). Conclusions. Detailed assessment of diagnostic performance by ROC curve analysis shows that, for planar imaging, 99mTc-labeled tetrofosmin enhances the detection of coronary artery disease compared with 201Tl.
AB - Background. Receiver operating characteristic (ROC) curve analysis provides detailed information about the performance of a diagnostic test. Methods and Results. As part of a multicenter phase III trial, 160 patients with known or suspected coronary artery disease underwent planar stress-rest 99mTc-labeled tetrofosmin and stress-redistribution 201Tl imaging within 14 days of each other, to compare the diagnostic accuracy of these imaging modalities by ROC curve analysis. Coronary arteriography was used as the reference standard and greater than 70% stenosis was considered significant. ROC curve analysis showed improved detection of coronary artery disease with 99mTc-labeled tetrofosmin compared with 201Tl, with ROC curve areas of 0.765 versus 0.644, respectively (p = 0.02), 99mTc-labeled tetrofosmin also better identified single-vessel disease in those without previous myocardial infarction (ROC curve areas of 0.684 vs 0.510 for 99mTc-labeled tetrofosmin and 201Tl, respectively; p = 0.04) and enhanced the detection of multivessel disease in those with previous myocardial infarction (ROC curve areas of 0.764 vs 0.638, respectively; p = 0.02). Conclusions. Detailed assessment of diagnostic performance by ROC curve analysis shows that, for planar imaging, 99mTc-labeled tetrofosmin enhances the detection of coronary artery disease compared with 201Tl.
KW - Coronary artery disease
KW - Receiver operating characteristic curve analysis
KW - Technetium 99m-labeled tetrofosmin
KW - Thallium-201
UR - http://www.scopus.com/inward/record.url?scp=0030772156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030772156&partnerID=8YFLogxK
U2 - 10.1016/S1071-3581(97)90106-9
DO - 10.1016/S1071-3581(97)90106-9
M3 - Article
VL - 4
SP - 291
EP - 297
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 4
ER -