Improved detection of recurrent bladder cancer using the bard BTA stat test

Michael F. Sarosdy, M'Liss A. Hudson, William J. Ellis, Mark S. Soloway, Ralph DeVere White, Joel Sheinfeld, Mark V. Jarowenko, Paul F. Schellhammer, Ed W. Schervish, Jay V. Patel, Gerald W. Chodak, Donald L. Lamm, Robert D. Johnson, Mary Henderson, George Adams, Brent A. Blumenstein, Kent R. Thoelke, Randy D. Pfalzgraf, Heather A. Murchison, Sharon L. Brunelle

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Abstract

Objectives. To evaluate the BTA stat Test in the detection of recurrent bladder cancer. Methods. Sensitivity and specificity were determined using frozen voided urine samples from patients with recurrent bladder cancer, volunteers, patients with nonurologic conditions, and patients with a history of bladder cancer but free of disease. Results of cytology and the original BTA Test were compared with the sensitivity of the BTA stat Test in a large subgroup of the patients with cancer. Results. The BTA stat Test detected 147 (67%) of 220 recurrent cancers. For those urine samples with previous cytologic and BTA Test results available, cytology had a sensitivity of 23%, the BTA Test 44%, and the BTA star Test 58% for detection of recurrent cancer (P < 0.001, star versus cytology). The specificity of the BTA star Test was 72% for benign genitourinary disease and 95% in healthy volunteers. Conclusions. The BTA star Test has high sensitivity and is significantly superior to voided urine cytologic analysis in the detection of recurrent bladder cancer.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalUrology
Volume50
Issue number3
DOIs
StatePublished - Sep 1 1997
Externally publishedYes

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Urinary Bladder Neoplasms
Cell Biology
Urine
Neoplasms
Volunteers
Healthy Volunteers
Sensitivity and Specificity

ASJC Scopus subject areas

  • Urology

Cite this

Sarosdy, M. F., Hudson, ML. A., Ellis, W. J., Soloway, M. S., White, R. D., Sheinfeld, J., ... Brunelle, S. L. (1997). Improved detection of recurrent bladder cancer using the bard BTA stat test. Urology, 50(3), 349-353. https://doi.org/10.1016/S0090-4295(97)00292-6

Improved detection of recurrent bladder cancer using the bard BTA stat test. / Sarosdy, Michael F.; Hudson, M'Liss A.; Ellis, William J.; Soloway, Mark S.; White, Ralph DeVere; Sheinfeld, Joel; Jarowenko, Mark V.; Schellhammer, Paul F.; Schervish, Ed W.; Patel, Jay V.; Chodak, Gerald W.; Lamm, Donald L.; Johnson, Robert D.; Henderson, Mary; Adams, George; Blumenstein, Brent A.; Thoelke, Kent R.; Pfalzgraf, Randy D.; Murchison, Heather A.; Brunelle, Sharon L.

In: Urology, Vol. 50, No. 3, 01.09.1997, p. 349-353.

Research output: Contribution to journalArticle

Sarosdy, MF, Hudson, MLA, Ellis, WJ, Soloway, MS, White, RD, Sheinfeld, J, Jarowenko, MV, Schellhammer, PF, Schervish, EW, Patel, JV, Chodak, GW, Lamm, DL, Johnson, RD, Henderson, M, Adams, G, Blumenstein, BA, Thoelke, KR, Pfalzgraf, RD, Murchison, HA & Brunelle, SL 1997, 'Improved detection of recurrent bladder cancer using the bard BTA stat test', Urology, vol. 50, no. 3, pp. 349-353. https://doi.org/10.1016/S0090-4295(97)00292-6
Sarosdy MF, Hudson MLA, Ellis WJ, Soloway MS, White RD, Sheinfeld J et al. Improved detection of recurrent bladder cancer using the bard BTA stat test. Urology. 1997 Sep 1;50(3):349-353. https://doi.org/10.1016/S0090-4295(97)00292-6
Sarosdy, Michael F. ; Hudson, M'Liss A. ; Ellis, William J. ; Soloway, Mark S. ; White, Ralph DeVere ; Sheinfeld, Joel ; Jarowenko, Mark V. ; Schellhammer, Paul F. ; Schervish, Ed W. ; Patel, Jay V. ; Chodak, Gerald W. ; Lamm, Donald L. ; Johnson, Robert D. ; Henderson, Mary ; Adams, George ; Blumenstein, Brent A. ; Thoelke, Kent R. ; Pfalzgraf, Randy D. ; Murchison, Heather A. ; Brunelle, Sharon L. / Improved detection of recurrent bladder cancer using the bard BTA stat test. In: Urology. 1997 ; Vol. 50, No. 3. pp. 349-353.
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abstract = "Objectives. To evaluate the BTA stat Test in the detection of recurrent bladder cancer. Methods. Sensitivity and specificity were determined using frozen voided urine samples from patients with recurrent bladder cancer, volunteers, patients with nonurologic conditions, and patients with a history of bladder cancer but free of disease. Results of cytology and the original BTA Test were compared with the sensitivity of the BTA stat Test in a large subgroup of the patients with cancer. Results. The BTA stat Test detected 147 (67{\%}) of 220 recurrent cancers. For those urine samples with previous cytologic and BTA Test results available, cytology had a sensitivity of 23{\%}, the BTA Test 44{\%}, and the BTA star Test 58{\%} for detection of recurrent cancer (P < 0.001, star versus cytology). The specificity of the BTA star Test was 72{\%} for benign genitourinary disease and 95{\%} in healthy volunteers. Conclusions. The BTA star Test has high sensitivity and is significantly superior to voided urine cytologic analysis in the detection of recurrent bladder cancer.",
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AU - White, Ralph DeVere

AU - Sheinfeld, Joel

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AU - Johnson, Robert D.

AU - Henderson, Mary

AU - Adams, George

AU - Blumenstein, Brent A.

AU - Thoelke, Kent R.

AU - Pfalzgraf, Randy D.

AU - Murchison, Heather A.

AU - Brunelle, Sharon L.

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N2 - Objectives. To evaluate the BTA stat Test in the detection of recurrent bladder cancer. Methods. Sensitivity and specificity were determined using frozen voided urine samples from patients with recurrent bladder cancer, volunteers, patients with nonurologic conditions, and patients with a history of bladder cancer but free of disease. Results of cytology and the original BTA Test were compared with the sensitivity of the BTA stat Test in a large subgroup of the patients with cancer. Results. The BTA stat Test detected 147 (67%) of 220 recurrent cancers. For those urine samples with previous cytologic and BTA Test results available, cytology had a sensitivity of 23%, the BTA Test 44%, and the BTA star Test 58% for detection of recurrent cancer (P < 0.001, star versus cytology). The specificity of the BTA star Test was 72% for benign genitourinary disease and 95% in healthy volunteers. Conclusions. The BTA star Test has high sensitivity and is significantly superior to voided urine cytologic analysis in the detection of recurrent bladder cancer.

AB - Objectives. To evaluate the BTA stat Test in the detection of recurrent bladder cancer. Methods. Sensitivity and specificity were determined using frozen voided urine samples from patients with recurrent bladder cancer, volunteers, patients with nonurologic conditions, and patients with a history of bladder cancer but free of disease. Results of cytology and the original BTA Test were compared with the sensitivity of the BTA stat Test in a large subgroup of the patients with cancer. Results. The BTA stat Test detected 147 (67%) of 220 recurrent cancers. For those urine samples with previous cytologic and BTA Test results available, cytology had a sensitivity of 23%, the BTA Test 44%, and the BTA star Test 58% for detection of recurrent cancer (P < 0.001, star versus cytology). The specificity of the BTA star Test was 72% for benign genitourinary disease and 95% in healthy volunteers. Conclusions. The BTA star Test has high sensitivity and is significantly superior to voided urine cytologic analysis in the detection of recurrent bladder cancer.

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