Improved coverage and accuracy with strand-conserving sequence enrichment

Toumy Guettouche, Stephan Zuchner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Targeted next-generation sequencing is becoming a common tool in the molecular diagnostic laboratory. However, currently available methods to enrich for regions of interest in the DNA sequence suffer from drawbacks such as high cost, complex protocols, lack of clinical-level accuracy and uneven target coverage. A target-enrichment approach using complementary long padlock probes described in a recent article significantly improves on previous methods in most of these areas. See related Research:

Original languageEnglish (US)
Article number46
JournalGenome Medicine
Issue number5
StatePublished - May 29 2013

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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