TY - JOUR
T1 - Improved conjunctival microcirculation in diabetic retinopathy patients with MTHFR polymorphisms after Ocufolin™ Administration
AU - Liu, Zhiping
AU - Jiang, Hong
AU - Townsend, Justin H.
AU - Wang, Jianhua
N1 - Funding Information:
This study was supported by research grants from Global healthcare Focus, NIH Center Grant P30 EY014801 , NINDS 1R01NS111115-01 (Wang), and a grant from the Research to Prevent Blindness (RPB). Visiting scholar activity (Dr. Zhiping Liu) was supported by the Guangzhou Municipal Science and Technology Project (No. 201804010038 ), and Natural Science Foundation of Guangdong Province (No. 2020A1515010276 ).
Funding Information:
This study was supported by research grants from Global Healthcare Focus, NIH Center Grant P30 EY014801 , NINDS 1R01NS111115-01 (Wang), and a grant from the Research to Prevent Blindness (RPB). Visiting scholar activity (Dr. Zhiping Liu) was supported by the Guangzhou Municipal Science and Technology Project (No. 201804010038 ), and Natural Science Foundation of Guangdong Province (No. 2020A1515010276 ).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/11
Y1 - 2020/11
N2 - Purpose: To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg L-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic acid, calcium salt), methylcobalamin, and other ingredients. Methods: Eight D + PM patients received Ocufolin™ for six months (6 M). Bulbar conjunctival microvasculature and microcirculation metrics, including vessel diameter (D), axial blood flow velocity (Va), cross-sectional blood flow velocity (Vs), flow rate (Q), and vessel density (VD, Dbox), were measured at baseline, 4 M, and 6 M. Results: The mean age was 54 ± 7 years. No significant demographic differences were found. Conjunctival microcirculation, measured as Va, Vs, and Q was significantly increased at 4 M and 6 M, compared to baseline. Va was 0.44 ± 0.10 mm/s, 0.58 ± 0.13 mm/s, 0.59 ± 0.13 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.01). Similarly, Vs was 0.31 ± 0.07 mm/s, 0.40 ± 0.09 mm/s, 0.41 ± 0.09 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). Q was 107.8 ± 49.4 pl/s, 178.0 ± 125.8 pl/s, 163.3 ± 85.8 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). The VD at 6 M was significantly higher than that at baseline (P = 0.017). Changes of D were positively correlated with changes of Va, Q, and VD. Effects of MTHFR and haptoglobin polymorphisms on the improvements of conjunctival microcirculation and microvasculature were found. Conclusions: Ocufolin™ supplementation improves conjunctival microcirculation in patients with diabetic retinopathy and common folate polymorphisms.
AB - Purpose: To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg L-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic acid, calcium salt), methylcobalamin, and other ingredients. Methods: Eight D + PM patients received Ocufolin™ for six months (6 M). Bulbar conjunctival microvasculature and microcirculation metrics, including vessel diameter (D), axial blood flow velocity (Va), cross-sectional blood flow velocity (Vs), flow rate (Q), and vessel density (VD, Dbox), were measured at baseline, 4 M, and 6 M. Results: The mean age was 54 ± 7 years. No significant demographic differences were found. Conjunctival microcirculation, measured as Va, Vs, and Q was significantly increased at 4 M and 6 M, compared to baseline. Va was 0.44 ± 0.10 mm/s, 0.58 ± 0.13 mm/s, 0.59 ± 0.13 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.01). Similarly, Vs was 0.31 ± 0.07 mm/s, 0.40 ± 0.09 mm/s, 0.41 ± 0.09 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). Q was 107.8 ± 49.4 pl/s, 178.0 ± 125.8 pl/s, 163.3 ± 85.8 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). The VD at 6 M was significantly higher than that at baseline (P = 0.017). Changes of D were positively correlated with changes of Va, Q, and VD. Effects of MTHFR and haptoglobin polymorphisms on the improvements of conjunctival microcirculation and microvasculature were found. Conclusions: Ocufolin™ supplementation improves conjunctival microcirculation in patients with diabetic retinopathy and common folate polymorphisms.
KW - Conjunctival microcirculation
KW - Conjunctival microvasculature
KW - Diabetes mellitus
KW - Diabetic retinopathy
KW - Functional slit-lamp biomicroscopy
KW - Haptoglobin
KW - L-methylfolate
KW - MTHFR
KW - Medical food
UR - http://www.scopus.com/inward/record.url?scp=85090270186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090270186&partnerID=8YFLogxK
U2 - 10.1016/j.mvr.2020.104066
DO - 10.1016/j.mvr.2020.104066
M3 - Article
C2 - 32860770
AN - SCOPUS:85090270186
VL - 132
JO - Microvascular Research
JF - Microvascular Research
SN - 0026-2862
M1 - 104066
ER -