Important roles of ERCC1 in DNA repair and targeted therapy

Jennifer Hu, J. De la Garza, S. K. Srinivasan, Ann Alyssa Kurian, Feng Gong

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The ERCC1 protein (excision repair cross-complementing rodent repair deficiency, complementation group 1) forms a heterodimer with the Xeroderma pigmentosum group F (XPF) endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The ERCC1-XPF heterodimer has an important role in genome maintenance. While most of the DNA repair proteins function only in a specific repair pathway, ERCC1-XPF is involved in multiple DNA repair pathways and telomere maintenance, making this heterodimer not only an attractive therapeutic target, but also a biomarker to predict treatment outcome.Springer Science+Business Media, LLC 2013.

Original languageEnglish (US)
Title of host publicationAdvances in DNA Repair in Cancer Therapy
PublisherSpringer New York
Pages129-142
Number of pages14
ISBN (Electronic)9781461447412
ISBN (Print)9781461447405
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Hu, J., De la Garza, J., Srinivasan, S. K., Kurian, A. A., & Gong, F. (2013). Important roles of ERCC1 in DNA repair and targeted therapy. In Advances in DNA Repair in Cancer Therapy (pp. 129-142). Springer New York. https://doi.org/10.1007/978-1-4614-4741-2_5