Importance of vascular responses in determining cortical oxygenation during recurrent paroxysmal events of varying duration and frequency of repetition

N. R. Kreisman, Thomas Sick, M. Rosenthal

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cerebral oxygenation initially increases and later decreases in rats subjected to experimental status epilepticus. In this study, we have compared cerebral oxygen supply and vascular changes during paroxysmal events of different durations and at different time intervals to test the hypothesis that oxygen insufficiency is associated more readily with paroxysmal events of greater intensity. Continuous measurements were made of local changes in cortical blood volume, redox levels of cytochrome a,a3, cortical PO2, and systemic arterial blood pressure during recurrent seizures induced by pentylenetetrazol or bicuculline. In contrast to expectations, systemic and cerebral vascular responses and associated increases in cerebral oxygenation were better maintained during long-duration ictal episodes than during short-duration ictal bursts, interictal spikes, or evoked potentials. Short-duration paroxysmal events were often accompanied by decreases in cerebral oxygenation, whereas long-duration events were still accompanied by increases in oxygenation. Ictal bursts occurring with short interburst intervals caused a more rapid failure of vascular responsiveness than those occurring at longer intervals. These relationships of intensity and frequency of repetition of seizures to changes in vascular responses indicate progressive dissociation of the normal tight couple between neuronal activity, energy demand, and cerebral blood flow during status epilepticus.

Original languageEnglish
Pages (from-to)330-338
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume3
Issue number3
StatePublished - Dec 1 1983
Externally publishedYes

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Blood Vessels
Status Epilepticus
Stroke
Cerebrovascular Circulation
Seizures
Oxygen
Pentylenetetrazole
Bicuculline
Electron Transport Complex IV
Blood Volume
Evoked Potentials
Action Potentials
Oxidation-Reduction
Arterial Pressure

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

Cite this

Importance of vascular responses in determining cortical oxygenation during recurrent paroxysmal events of varying duration and frequency of repetition. / Kreisman, N. R.; Sick, Thomas; Rosenthal, M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 3, No. 3, 01.12.1983, p. 330-338.

Research output: Contribution to journalArticle

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