Importance of resolving fungal nomenclature: The case of multiple pathogenic species in the Cryptococcus genus

Ferry Hagen, H. Thorsten Lumbsch, Valentina Arsic Arsenijevic, Hamid Badali, Sebastien Bertout, R. Blake Billmyre, M. Rosa Bragulat, F. Javier Cabañes, Mauricio Carbia, Arunaloke Chakrabarti, Sudha Chaturvedi, Vishnu Chaturvedi, Min Chen, Anuradha Chowdhary, Maria Francisca Colom, Oliver A. Cornely, Pedro W. Crous, Maria S. Cuétara, Mara Diaz, Ana Espinel-IngroffHamed Fakhim, Rama Falk, Wenjie Fang, Patricia F. Herkert, Consuelo Ferrer Rodríguez, James A. Fraser, Josepa Gené, Josep Guarro, Alexander Idnurm, María Teresa Illnait-Zaragozi, Ziauddin Khan, Kantarawee Khayhan, Anna Kolecka, Cletus P. Kurtzman, Katrien Lagrou, Wanqing Liao, Carlos Linares, Jacques F. Meis, Kirsten Nielsen, Tinashe K. Nyazika, Weihua Pan, Marina Pekmezovic, Itzhack Polacheck, Brunella Posteraro, Flavio de Queiroz Telles Filho, Orazio Romeo, Manuel Sánchez, Ana Sampaio, Maurizio Sanguinetti, Pojana Sriburee, Takashi Sugita, Saad J. Taj-Aldeen, Masako Takashima, John W. Taylor, Bart Theelen, Rok Tomazin, Paul E. Verweij, Retno Wahyuningsih, Ping Wang, Teun Boekhout

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Cryptococcosis is a major fungal disease caused by members of the Cryptococcus gattii and Cryptococcus neoformans species complexes. After more than 15 years of molecular genetic and phenotypic studies and much debate, a proposal for a taxonomic revision was made. The two varieties within C. neoformans were raised to species level, and the same was done for five genotypes within C. gattii. In a recent perspective (K. J. Kwon-Chung et al., mSphere 2:e00357-16, 2017, https://doi .org/10.1128/mSphere.00357-16), it was argued that this taxonomic proposal was premature and without consensus in the community. Although the authors of the perspective recognized the existence of genetic diversity, they preferred the use of the informal nomenclature "C. neoformans species complex" and "C. gattii species complex." Here we highlight the advantage of recognizing these seven species, as ignoring these species will impede deciphering further biologically and clinically relevant differences between them, which may in turn delay future clinical advances.

Original languageEnglish (US)
Article numbere00238-17
JournalmSphere
Volume2
Issue number4
DOIs
StatePublished - Jul 1 2017

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Cryptococcus gattii
Cryptococcus
Cryptococcus neoformans
Terminology
Cryptococcosis
Mycoses
Molecular Biology
Genotype

Keywords

  • Cryptococcosis
  • Cryptococcus
  • Diagnostics
  • Species delimitation
  • Taxonomy

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Hagen, F., Lumbsch, H. T., Arsenijevic, V. A., Badali, H., Bertout, S., Billmyre, R. B., ... Boekhout, T. (2017). Importance of resolving fungal nomenclature: The case of multiple pathogenic species in the Cryptococcus genus. mSphere, 2(4), [e00238-17]. https://doi.org/10.1128/mSphere.00238-17

Importance of resolving fungal nomenclature : The case of multiple pathogenic species in the Cryptococcus genus. / Hagen, Ferry; Lumbsch, H. Thorsten; Arsenijevic, Valentina Arsic; Badali, Hamid; Bertout, Sebastien; Billmyre, R. Blake; Bragulat, M. Rosa; Cabañes, F. Javier; Carbia, Mauricio; Chakrabarti, Arunaloke; Chaturvedi, Sudha; Chaturvedi, Vishnu; Chen, Min; Chowdhary, Anuradha; Colom, Maria Francisca; Cornely, Oliver A.; Crous, Pedro W.; Cuétara, Maria S.; Diaz, Mara; Espinel-Ingroff, Ana; Fakhim, Hamed; Falk, Rama; Fang, Wenjie; Herkert, Patricia F.; Rodríguez, Consuelo Ferrer; Fraser, James A.; Gené, Josepa; Guarro, Josep; Idnurm, Alexander; Illnait-Zaragozi, María Teresa; Khan, Ziauddin; Khayhan, Kantarawee; Kolecka, Anna; Kurtzman, Cletus P.; Lagrou, Katrien; Liao, Wanqing; Linares, Carlos; Meis, Jacques F.; Nielsen, Kirsten; Nyazika, Tinashe K.; Pan, Weihua; Pekmezovic, Marina; Polacheck, Itzhack; Posteraro, Brunella; Filho, Flavio de Queiroz Telles; Romeo, Orazio; Sánchez, Manuel; Sampaio, Ana; Sanguinetti, Maurizio; Sriburee, Pojana; Sugita, Takashi; Taj-Aldeen, Saad J.; Takashima, Masako; Taylor, John W.; Theelen, Bart; Tomazin, Rok; Verweij, Paul E.; Wahyuningsih, Retno; Wang, Ping; Boekhout, Teun.

In: mSphere, Vol. 2, No. 4, e00238-17, 01.07.2017.

Research output: Contribution to journalArticle

Hagen, F, Lumbsch, HT, Arsenijevic, VA, Badali, H, Bertout, S, Billmyre, RB, Bragulat, MR, Cabañes, FJ, Carbia, M, Chakrabarti, A, Chaturvedi, S, Chaturvedi, V, Chen, M, Chowdhary, A, Colom, MF, Cornely, OA, Crous, PW, Cuétara, MS, Diaz, M, Espinel-Ingroff, A, Fakhim, H, Falk, R, Fang, W, Herkert, PF, Rodríguez, CF, Fraser, JA, Gené, J, Guarro, J, Idnurm, A, Illnait-Zaragozi, MT, Khan, Z, Khayhan, K, Kolecka, A, Kurtzman, CP, Lagrou, K, Liao, W, Linares, C, Meis, JF, Nielsen, K, Nyazika, TK, Pan, W, Pekmezovic, M, Polacheck, I, Posteraro, B, Filho, FDQT, Romeo, O, Sánchez, M, Sampaio, A, Sanguinetti, M, Sriburee, P, Sugita, T, Taj-Aldeen, SJ, Takashima, M, Taylor, JW, Theelen, B, Tomazin, R, Verweij, PE, Wahyuningsih, R, Wang, P & Boekhout, T 2017, 'Importance of resolving fungal nomenclature: The case of multiple pathogenic species in the Cryptococcus genus', mSphere, vol. 2, no. 4, e00238-17. https://doi.org/10.1128/mSphere.00238-17
Hagen F, Lumbsch HT, Arsenijevic VA, Badali H, Bertout S, Billmyre RB et al. Importance of resolving fungal nomenclature: The case of multiple pathogenic species in the Cryptococcus genus. mSphere. 2017 Jul 1;2(4). e00238-17. https://doi.org/10.1128/mSphere.00238-17
Hagen, Ferry ; Lumbsch, H. Thorsten ; Arsenijevic, Valentina Arsic ; Badali, Hamid ; Bertout, Sebastien ; Billmyre, R. Blake ; Bragulat, M. Rosa ; Cabañes, F. Javier ; Carbia, Mauricio ; Chakrabarti, Arunaloke ; Chaturvedi, Sudha ; Chaturvedi, Vishnu ; Chen, Min ; Chowdhary, Anuradha ; Colom, Maria Francisca ; Cornely, Oliver A. ; Crous, Pedro W. ; Cuétara, Maria S. ; Diaz, Mara ; Espinel-Ingroff, Ana ; Fakhim, Hamed ; Falk, Rama ; Fang, Wenjie ; Herkert, Patricia F. ; Rodríguez, Consuelo Ferrer ; Fraser, James A. ; Gené, Josepa ; Guarro, Josep ; Idnurm, Alexander ; Illnait-Zaragozi, María Teresa ; Khan, Ziauddin ; Khayhan, Kantarawee ; Kolecka, Anna ; Kurtzman, Cletus P. ; Lagrou, Katrien ; Liao, Wanqing ; Linares, Carlos ; Meis, Jacques F. ; Nielsen, Kirsten ; Nyazika, Tinashe K. ; Pan, Weihua ; Pekmezovic, Marina ; Polacheck, Itzhack ; Posteraro, Brunella ; Filho, Flavio de Queiroz Telles ; Romeo, Orazio ; Sánchez, Manuel ; Sampaio, Ana ; Sanguinetti, Maurizio ; Sriburee, Pojana ; Sugita, Takashi ; Taj-Aldeen, Saad J. ; Takashima, Masako ; Taylor, John W. ; Theelen, Bart ; Tomazin, Rok ; Verweij, Paul E. ; Wahyuningsih, Retno ; Wang, Ping ; Boekhout, Teun. / Importance of resolving fungal nomenclature : The case of multiple pathogenic species in the Cryptococcus genus. In: mSphere. 2017 ; Vol. 2, No. 4.
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AU - Bertout, Sebastien

AU - Billmyre, R. Blake

AU - Bragulat, M. Rosa

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AU - Chowdhary, Anuradha

AU - Colom, Maria Francisca

AU - Cornely, Oliver A.

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AU - Cuétara, Maria S.

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AU - Idnurm, Alexander

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AU - Nyazika, Tinashe K.

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