Importance of premeal injection time in insulin therapy: Humalog Mix25 is convenient for improved post-prandial glycemic control in type 2 diabetic patients with Italian dietary habits

C. Coscelli, Gianluca Iacobellis, C. Calderini, R. Carleo, M. Gobbo, U. Di Mario, F. Leonetti, A. Galluzzo, V. Pirrone, M. Lunetta, P. Casale, F. Paleari, C. Falcelli, D. Valle, A. Camporeale, D. Merante

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We investigated the use, in a short period, of Humalog Mix25 (Mix25) in a twice-daily administration regimen compared to a twice-daily injection therapy with Humulin 30/70 (30/70) in diabetic patients with Italian dietary habits. We studied 33 type 2 diabetic patients aged 59.1±8.1 years, BMI 29.8±2.7 kg/m2, duration of diabetes and insulin therapy of 14.4±9.8 and 4.2±4.6 years, respectively. After a 4-day lead-in period of twice-daily human insulin 30/70 treatment, patients were randomized to one of two treatment sequences: (1) a twice-daily regimen with Mix25 just 5 minutes before the morning and evening meals for 12 days, followed by a twice-daily therapy with human insulin 30/70 given 30 minutes before the morning and evening meals for an additional 12 days; or (2) the alternate sequence. Each patient underwent a mixed meal test: Humulin 30/70 was administered 30 minutes before the meal, while Mix25 was given 5 minutes before. The 2-hour post-prandial glucose concentration after breakfast was significantly lower during treatment with Mix25 than with Humulin 30/70 (157±43.2 vs. 180±43.2 mg/dl, p<0.05). The glycemic excursion after dinner on Mix25 treatment was significantly lower than with Humulin 30/70 (12.2±48.01 vs. 35.5±36.92 mg/dl, p<0.05). AUC glucose after Mix25 was lower than after Humulin 30/70. Glycemia after test meal was significantly lower with Mix25 than with Humulin 30/70. Insulin and free insulin concentrations after the test meal were significantly higher with Mix25 in comparison to Humulin 30/70. AUC serum insulin and free insulin curves after Mix25 were significantly higher than after Humulin 30/70 (p=0.028 and p=0.005, respectively). Twice-daily injections of Humalog Mix25, compared to human insulin 30/70 in type 2 diabetic patients with Italian dietary habits, provide improved and lasting post-prandial glycemic control, with the great convenience of the injection just before the meal.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalActa Diabetologica
Volume40
Issue number4
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Fingerprint

Insulin, Regular, Human
Feeding Behavior
Meals
Insulin
Injections
Breakfast
Therapeutics
Area Under Curve
Glucose
insulin lispro, isophane insulin lispro drug combination (25:75)

Keywords

  • Humalog Mix25
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Importance of premeal injection time in insulin therapy : Humalog Mix25 is convenient for improved post-prandial glycemic control in type 2 diabetic patients with Italian dietary habits. / Coscelli, C.; Iacobellis, Gianluca; Calderini, C.; Carleo, R.; Gobbo, M.; Di Mario, U.; Leonetti, F.; Galluzzo, A.; Pirrone, V.; Lunetta, M.; Casale, P.; Paleari, F.; Falcelli, C.; Valle, D.; Camporeale, A.; Merante, D.

In: Acta Diabetologica, Vol. 40, No. 4, 01.12.2003, p. 187-192.

Research output: Contribution to journalArticle

Coscelli, C, Iacobellis, G, Calderini, C, Carleo, R, Gobbo, M, Di Mario, U, Leonetti, F, Galluzzo, A, Pirrone, V, Lunetta, M, Casale, P, Paleari, F, Falcelli, C, Valle, D, Camporeale, A & Merante, D 2003, 'Importance of premeal injection time in insulin therapy: Humalog Mix25 is convenient for improved post-prandial glycemic control in type 2 diabetic patients with Italian dietary habits', Acta Diabetologica, vol. 40, no. 4, pp. 187-192. https://doi.org/10.1007/s00592-003-0110-2
Coscelli, C. ; Iacobellis, Gianluca ; Calderini, C. ; Carleo, R. ; Gobbo, M. ; Di Mario, U. ; Leonetti, F. ; Galluzzo, A. ; Pirrone, V. ; Lunetta, M. ; Casale, P. ; Paleari, F. ; Falcelli, C. ; Valle, D. ; Camporeale, A. ; Merante, D. / Importance of premeal injection time in insulin therapy : Humalog Mix25 is convenient for improved post-prandial glycemic control in type 2 diabetic patients with Italian dietary habits. In: Acta Diabetologica. 2003 ; Vol. 40, No. 4. pp. 187-192.
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AU - Calderini, C.

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AU - Gobbo, M.

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AU - Leonetti, F.

AU - Galluzzo, A.

AU - Pirrone, V.

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AU - Casale, P.

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