Importance of β-catenin in glucose and energy homeostasis

Lynda Elghazi, Aaron P. Gould, Aaron J. Weiss, Daniel J. Barker, John Callaghan, Darren Opland, Martin Myers, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

In settings of increased insulin demand, failure to expand pancreatic β-cells mass leads to diabetes. Genome-wide scans of diabetic populations have uncovered several genes associated with susceptibility to type 2 diabetes and a number of them are part of the Wnt signaling. β-Catenin, a Wnt downstream effector participates in pancreatic development, however, little is known about its action in mature β-cells. Deletion of β-Catenin in Pdx1 pancreatic progenitors leads to a decreased β-cell mass and impaired glucose tolerance. Surprisingly, loss of β-catenin made these mice resistant to high fat diet because of their increased energy expenditure and insulin sensitivity due to hyperactivity. The complexity of this phenotype was also explained in part by ectopic expression of Cre recombinase in the hypothalamus. Our data implicates β-Catenin in the regulation of metabolism and energy homeostasis and suggest that Wnt signaling modulates the susceptibility to diabetes by acting on different tissues.

Original languageEnglish (US)
Article number693
JournalScientific reports
Volume2
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • General

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    Elghazi, L., Gould, A. P., Weiss, A. J., Barker, D. J., Callaghan, J., Opland, D., Myers, M., Cras-Méneur, C., & Bernal-Mizrachi, E. (2012). Importance of β-catenin in glucose and energy homeostasis. Scientific reports, 2, [693]. https://doi.org/10.1038/srep00693