Implications of Sphingolipid Metabolites in Kidney Diseases

Shamroop Kumar Mallela, Sandra Merscher, Alessia Fornoni

Research output: Contribution to journalReview articlepeer-review

Abstract

Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can be lethal to cells. Abnormalities in the levels of sphingolipids are associated with several human diseases including kidney diseases. Several studies demonstrate that sphingolipids play an important role in maintaining proper renal function. Sphingolipids can alter the glomerular filtration barrier by affecting the functioning of podocytes, which are key cellular components of the glomerular filtration barrier. This review summarizes the studies in our understanding of the regulation of sphingolipid signaling in kidney diseases, especially in glomerular and tubulointerstitial diseases, and the potential to target sphingolipid pathways in developing therapeutics for the treatment of renal diseases.

Original languageEnglish (US)
Article number4244
JournalInternational journal of molecular sciences
Volume23
Issue number8
DOIs
StatePublished - Apr 1 2022
Externally publishedYes

Keywords

  • glomerular diseases
  • sphingolipids
  • tubulointerstitial diseases

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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