Implications of positive surgical margins

John R. Jacobs, Kurshid Ahmad, Roy Casiano, David E. Schuller, Charles Scott, George E. Laramore, Muhyi Al-Sarraf

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


The recently concluded Head and Neck Intergroup trial tested the addition of three courses of cis-platinum containing chemotherapy to standard treatment of surgery and postoperative radiotherapy for patients with advanced operable squamous cell carcinoma of the head and neck. Only patients with negative surgical margins were eligible for the trial. One hundred twelve patients with positive surgical margins were dropped from the trial but continued to be followed. These patients received a variety of treatments. Positive surgical margins were most often seen in nonglottic primaries and with increasing frequency as the N stage increased. Patients with positive margins who achieved a complete clinical response to subsequent treatment had a median survival of 33.8 months vs. 9.1 months for those with less than a complete clinical response. The addition of chemotherapy did not significantly alter the median survival of the positive margin patients.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
Issue number1
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Implications of positive surgical margins'. Together they form a unique fingerprint.

Cite this