Abstract
The risk of sudden death is highest early after myocardial infarction (MI) and progressively declines over the ensuing 6 to 12 months. Nevertheless, several randomized clinical trials have failed to show a survival benefit for implantable cardioverter-defibrillators when implanted early after MI in high-risk patients. The etiology of this acute MI-sudden cardiac death paradox is unclear, but may be related to the changing nature of the substrate over the several month period after acute MI. Further investigation is needed to delineate the actual causes of death in the early post-MI period and which interventions can be implemented to reduce the increased rate of sudden death that is observed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2001-2005 |
| Number of pages | 5 |
| Journal | Journal of the American College of Cardiology |
| Volume | 54 |
| Issue number | 22 |
| DOIs | |
| State | Published - Nov 24 2009 |
| Externally published | Yes |
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Keywords
- implantable defibrillator
- myocardial infarction
- sudden death
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Implantable Cardioverter-Defibrillator Therapy After Acute Myocardial Infarction. The Results Are Not Shocking. / Goldberger, Jeffrey; Passman, Rod.
In: Journal of the American College of Cardiology, Vol. 54, No. 22, 24.11.2009, p. 2001-2005.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Implantable Cardioverter-Defibrillator Therapy After Acute Myocardial Infarction. The Results Are Not Shocking
AU - Goldberger, Jeffrey
AU - Passman, Rod
PY - 2009/11/24
Y1 - 2009/11/24
N2 - The risk of sudden death is highest early after myocardial infarction (MI) and progressively declines over the ensuing 6 to 12 months. Nevertheless, several randomized clinical trials have failed to show a survival benefit for implantable cardioverter-defibrillators when implanted early after MI in high-risk patients. The etiology of this acute MI-sudden cardiac death paradox is unclear, but may be related to the changing nature of the substrate over the several month period after acute MI. Further investigation is needed to delineate the actual causes of death in the early post-MI period and which interventions can be implemented to reduce the increased rate of sudden death that is observed.
AB - The risk of sudden death is highest early after myocardial infarction (MI) and progressively declines over the ensuing 6 to 12 months. Nevertheless, several randomized clinical trials have failed to show a survival benefit for implantable cardioverter-defibrillators when implanted early after MI in high-risk patients. The etiology of this acute MI-sudden cardiac death paradox is unclear, but may be related to the changing nature of the substrate over the several month period after acute MI. Further investigation is needed to delineate the actual causes of death in the early post-MI period and which interventions can be implemented to reduce the increased rate of sudden death that is observed.
KW - implantable defibrillator
KW - myocardial infarction
KW - sudden death
UR - http://www.scopus.com/inward/record.url?scp=71849085003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71849085003&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2009.08.018
DO - 10.1016/j.jacc.2009.08.018
M3 - Review article
VL - 54
SP - 2001
EP - 2005
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 22
ER -