IMPAIRMENT OF PLATELET FUNCTION BY GROWTH-HORMONE RELEASE- INHIBITING HORMONE

G. M. Besser; A. M. Paxton; S. A.N. Johnson; E. J. Moody; C. H. Mortimer; R. Hall; A. Gomez-Pan; A. V. Schally; A. J. Kastin; D. H. Coy

doi:10.1016/S0140-6736(75)93139-6

IMPAIRMENT OF PLATELET FUNCTION BY GROWTH-HORMONE RELEASE- INHIBITING HORMONE

G. M. Besser, A. M. Paxton, S. A.N. Johnson, E. J. Moody, C. H. Mortimer, R. Hall, A. Gomez-Pan, A. V. Schally, A. J. Kastin, D. H. Coy

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32 Scopus citations

Abstract

Synthetic cyclic growth-hormone release-inhibiting hormone (G.H.-R.I.H) impaired platelet aggregation in each of four healthy men given 6-hour infusions. The effects lasted over 24 hours in three of them. There was no consistent change in platelet-counts during the infusions, but 18 hours after the end of the infusions there was a slight but significant increase in platelet-count. There was no change in prothrombin-time, partial thromboplastin-time, fibrinogen titres, and fibrinogen-degradation products. Incubation of G.H.-R.I.H. with blood in vitro did not affect platelet aggregation. Similar impairment of platelet function has been reported by others in baboons given linear G.H.-R.I.H. Infusions in the four healthy men studied also produced abdominal pain, dizziness, and diarrhœa in three, as have been reported in patients similarly infused. Although other side-effects or impairment of platelet-counts or bleeding-tendencies have not been reported in patients infused for up to 72 hours, caution should be exercised when using G.H.-R.I.H. over extended periods until further data on its toxicity are available.

Original language	English (US)
Pages (from-to)	1166-1168
Number of pages	3
Journal	The Lancet
Volume	305
Issue number	7917
DOIs	https://doi.org/10.1016/S0140-6736(75)93139-6
State	Published - May 24 1975
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Besser, G. M., Paxton, A. M., Johnson, S. A. N., Moody, E. J., Mortimer, C. H., Hall, R., Gomez-Pan, A., Schally, A. V., Kastin, A. J., & Coy, D. H. (1975). IMPAIRMENT OF PLATELET FUNCTION BY GROWTH-HORMONE RELEASE- INHIBITING HORMONE. The Lancet, 305(7917), 1166-1168. https://doi.org/10.1016/S0140-6736(75)93139-6

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title = "IMPAIRMENT OF PLATELET FUNCTION BY GROWTH-HORMONE RELEASE- INHIBITING HORMONE",

abstract = "Synthetic cyclic growth-hormone release-inhibiting hormone (G.H.-R.I.H) impaired platelet aggregation in each of four healthy men given 6-hour infusions. The effects lasted over 24 hours in three of them. There was no consistent change in platelet-counts during the infusions, but 18 hours after the end of the infusions there was a slight but significant increase in platelet-count. There was no change in prothrombin-time, partial thromboplastin-time, fibrinogen titres, and fibrinogen-degradation products. Incubation of G.H.-R.I.H. with blood in vitro did not affect platelet aggregation. Similar impairment of platelet function has been reported by others in baboons given linear G.H.-R.I.H. Infusions in the four healthy men studied also produced abdominal pain, dizziness, and diarrh{\oe}a in three, as have been reported in patients similarly infused. Although other side-effects or impairment of platelet-counts or bleeding-tendencies have not been reported in patients infused for up to 72 hours, caution should be exercised when using G.H.-R.I.H. over extended periods until further data on its toxicity are available.",

author = "Besser, {G. M.} and Paxton, {A. M.} and Johnson, {S. A.N.} and Moody, {E. J.} and Mortimer, {C. H.} and R. Hall and A. Gomez-Pan and Schally, {A. V.} and Kastin, {A. J.} and Coy, {D. H.}",

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AU - Moody, E. J.

AU - Mortimer, C. H.

AU - Hall, R.

AU - Gomez-Pan, A.

AU - Schally, A. V.

AU - Kastin, A. J.

AU - Coy, D. H.

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