@article{14dc6e0e799d480eb18d6ba110ec62b2,
title = "IMPAIRMENT OF PLATELET FUNCTION BY GROWTH-HORMONE RELEASE- INHIBITING HORMONE",
abstract = "Synthetic cyclic growth-hormone release-inhibiting hormone (G.H.-R.I.H) impaired platelet aggregation in each of four healthy men given 6-hour infusions. The effects lasted over 24 hours in three of them. There was no consistent change in platelet-counts during the infusions, but 18 hours after the end of the infusions there was a slight but significant increase in platelet-count. There was no change in prothrombin-time, partial thromboplastin-time, fibrinogen titres, and fibrinogen-degradation products. Incubation of G.H.-R.I.H. with blood in vitro did not affect platelet aggregation. Similar impairment of platelet function has been reported by others in baboons given linear G.H.-R.I.H. Infusions in the four healthy men studied also produced abdominal pain, dizziness, and diarrh{\oe}a in three, as have been reported in patients similarly infused. Although other side-effects or impairment of platelet-counts or bleeding-tendencies have not been reported in patients infused for up to 72 hours, caution should be exercised when using G.H.-R.I.H. over extended periods until further data on its toxicity are available.",
author = "Besser, {G. M.} and Paxton, {A. M.} and Johnson, {S. A.N.} and Moody, {E. J.} and Mortimer, {C. H.} and R. Hall and A. Gomez-Pan and Schally, {A. V.} and Kastin, {A. J.} and Coy, {D. H.}",
note = "Funding Information: the termination of the infusion. One had transient diarrhoea. Serum-amylase estimations in these two patients were normal; both were well by the next day. These symptoms may be due to inhibition of the secretion of gastrointestinal hor- mones or to direct actions of the polypeptide on gut motility. None of the patients having 24-72-hour infusions showed changes in platelet-counts during or after G.H.-R.I.H. administration. It seems probable that the therapeutic use of G.H.- R.I.H. will involve its long-term administration to patients. In view of the side-effects reported here in man, and those demonstrated by others in acute and long-term studies in baboons, caution should be exer- cised in studies using this material, either in its linear or cyclic form, over extended periods until further data on this compound{\textquoteright}s toxicity are available. How- ever, we have seen no evidence of a bleeding-tendency or other harmful effects in any of our studies involving infusions of this material for up to 72 hours. It is even possible that such effects on platelets might be beneficial in some diseases. We thank Dr Donna J. Koerker, Dr L. A. Harker, and Dr C. J. Goodner for discussing the detailed results of their baboon studies before publication and allowing us to refer to them; Dr M. Beard for hmmatological advice; and Mrs R. Hunt, Mrs J. Roberts, and Mr A. Oxley for technical assistance. Our work is supported by the Medical Research Council, the Joint Research Board of St. Bartholomew{\textquoteright}s Hospital, the Peel Research Trust, and the Scientific and Research Committee of Newcastle Area Health Authority (Teaching). Requests for reprints should be addressed to G.",
year = "1975",
month = may,
day = "24",
doi = "10.1016/S0140-6736(75)93139-6",
language = "English (US)",
volume = "305",
pages = "1166--1168",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7917",
}