Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control

F. Crosti, A. Secchi, E. Ferrero, L. Falqui, Luca A Inverardi, A. E. Pontiroli, G. F. Ciboddo, D. Pavoni, P. Protti, C. Rugarli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Impairment of suppressor-cell activity may be important in the pathogenesis and maintenance of insulin-dependent diabetes mellitus (IDDM). In 23 recent-onset IDDM patients, lymphocyte sensitivity in vitro to theophylline was tested both in basal conditions and after improvement of metabolic control. This pharmacologic agent is mainly effective on a lymphocytic subpopulation with phenotypic and functional suppressive features. Peripheral blood lymphocytes from IDDM patients showed a loss of theophylline sensitivity, identified as inhibition of both E-rosette formation and blastogenic response to polyclonal mitogens concanavalin A (ConA) and phytohemagglutinin (PHA). An inverse relationship was demonstrated between the theophylline-induced suppression of ConA blastogenic response and blood glucose and glycosylated hemoglobin levels (P < .01). Metabolic control seemed to be important even in relation to lymphocyte subpopulation distribution. In IDDM patients we found a significant (P < .05) reduction of OKT4+ lymphocytes that is correlated with blood glucose and glycosylated hemoglobin levels (P < .01). The improvement of metabolic control led to recovery of theophylline sensitivity. We suggest a deficiency in a suppressive system that could be involved in IDDM onset and the possible role of metabolic control in the impairment of some immunologic functions reported with this pathologic condition.

Original languageEnglish
Pages (from-to)1053-1057
Number of pages5
JournalDiabetes
Volume35
Issue number9
StatePublished - Dec 10 1986
Externally publishedYes

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Type 1 Diabetes Mellitus
Theophylline
Lymphocytes
Glycosylated Hemoglobin A
Concanavalin A
Blood Glucose
Rosette Formation
Lymphocyte Subsets
Phytohemagglutinins
Mitogens
Maintenance
hemoglobin P

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Crosti, F., Secchi, A., Ferrero, E., Falqui, L., Inverardi, L. A., Pontiroli, A. E., ... Rugarli, C. (1986). Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control. Diabetes, 35(9), 1053-1057.

Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control. / Crosti, F.; Secchi, A.; Ferrero, E.; Falqui, L.; Inverardi, Luca A; Pontiroli, A. E.; Ciboddo, G. F.; Pavoni, D.; Protti, P.; Rugarli, C.

In: Diabetes, Vol. 35, No. 9, 10.12.1986, p. 1053-1057.

Research output: Contribution to journalArticle

Crosti, F, Secchi, A, Ferrero, E, Falqui, L, Inverardi, LA, Pontiroli, AE, Ciboddo, GF, Pavoni, D, Protti, P & Rugarli, C 1986, 'Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control', Diabetes, vol. 35, no. 9, pp. 1053-1057.
Crosti F, Secchi A, Ferrero E, Falqui L, Inverardi LA, Pontiroli AE et al. Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control. Diabetes. 1986 Dec 10;35(9):1053-1057.
Crosti, F. ; Secchi, A. ; Ferrero, E. ; Falqui, L. ; Inverardi, Luca A ; Pontiroli, A. E. ; Ciboddo, G. F. ; Pavoni, D. ; Protti, P. ; Rugarli, C. / Impairment of lymphocyte-suppressive system in recent-onset insulin-dependent diabetes mellitus. Correlation with metabolic control. In: Diabetes. 1986 ; Vol. 35, No. 9. pp. 1053-1057.
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