Impairment of cerebral vasoreactivity (CVR) in patients with multi-infarct dementia

T. Rundek, V. Demarin, B. Kittner

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In order to assess cerebral vasoreactive capacity in patients with multi-infarct dementia (MID), 36 patients were analyzed by psychological rating scales (FMMS, GBS, SCAG) and Transcranial Doppler (TCD) with acetazolamide (AZT) test. The results have shown impairment of TCD findings in all patients before AZT stimulation, indicating vascular origin of disease. After AZT stimulation reduced cerebral vasoreactivity was observed in patients with severe mental deterioration, with SCAG >56, GBS >52 and FMMS <25 (p < 0.01), indicating exhausted cerebral vasoreactive capacity, probably due to reduced metabolic brain demands. In conclusion, AZT test combined with TCD is helpful in clarifying the haemodynamic origin of MID.

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalActa Clinica Croatica
Issue number1-2
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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