Impairment of cerebral vasoreactivity (CVR) in multiinfarct dementia (MID), dementia of Alzheimer's type (DAT), and dementia in Parkinson's disease (DPD)

Tatjana Rundek, V. Demarin, G. Savin

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2 Citations (Scopus)

Abstract

Background and purpose: The impaired cerebral vasoreactivity (CVT) occurs in severe dementia and may significantly reduce survival. In order to analyze the range of CVR in dementia we analyzed 30 patients with multi-infarct dementia (MID), 45 with dementia of Alzheimer's type (DAT), and 20 patients with dementia in Parkinson's disease (DPD). Methods: All patients fulfilled the criteria of DSM-III-R, NINDS-AIREN and NINCDS-ADRDA classification for dementia. Folstein-Mini-Mental Scale (FMMS) was used as a measure of the cognitive impairment and Hachinski ischemic score to distinguish vascular dementia. In all the patients we performed brain CT, Color Doppler Flow Imaging of the carotid and vertebral arteries and a battery of psychological rating scales and tests. Cerebral vasoreactivity was assessed by measuring the changes of blood now velocities with Transcranial Doppler after administration of acetazolamide (AZT). Results: The results showed the impairment of blood flow velocities in the Willis' circle in all MID patients before AZT stimulation, in 49% with DAT, and 20% with DPD. After the AZT stimulation the reduced CVR was observed in MID patients with the moderate and severe mental deterioration, and in those DAT and DPD patients who had the impaired TCD finding before the AZT test (p<0.01). Conclusion: Testing of the cerebral vasoreactivity can clarify the hemodynamic origin of dementia, indicating the basic different pathogeneity among various types of dementia and, therefore, predict the progression and the prognosis of disease.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalPeriodicum Biologorum
Volume97
Issue number2
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Multi-Infarct Dementia
dementia
Parkinson disease
Parkinson Disease
Dementia
Alzheimer Disease
Blood
Acetazolamide
Hemodynamics
Flow velocity
Deterioration
Brain
National Institute of Neurological Disorders and Stroke
Circle of Willis
Color
Imaging techniques
Vascular Dementia
Vertebral Artery
Blood Flow Velocity
Testing

Keywords

  • Cerebral vasoreactivity
  • Dementia of Alzheimer's type
  • Parkinson's disease
  • Transcranial Doppler (TCD)
  • Vascular dementia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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title = "Impairment of cerebral vasoreactivity (CVR) in multiinfarct dementia (MID), dementia of Alzheimer's type (DAT), and dementia in Parkinson's disease (DPD)",
abstract = "Background and purpose: The impaired cerebral vasoreactivity (CVT) occurs in severe dementia and may significantly reduce survival. In order to analyze the range of CVR in dementia we analyzed 30 patients with multi-infarct dementia (MID), 45 with dementia of Alzheimer's type (DAT), and 20 patients with dementia in Parkinson's disease (DPD). Methods: All patients fulfilled the criteria of DSM-III-R, NINDS-AIREN and NINCDS-ADRDA classification for dementia. Folstein-Mini-Mental Scale (FMMS) was used as a measure of the cognitive impairment and Hachinski ischemic score to distinguish vascular dementia. In all the patients we performed brain CT, Color Doppler Flow Imaging of the carotid and vertebral arteries and a battery of psychological rating scales and tests. Cerebral vasoreactivity was assessed by measuring the changes of blood now velocities with Transcranial Doppler after administration of acetazolamide (AZT). Results: The results showed the impairment of blood flow velocities in the Willis' circle in all MID patients before AZT stimulation, in 49{\%} with DAT, and 20{\%} with DPD. After the AZT stimulation the reduced CVR was observed in MID patients with the moderate and severe mental deterioration, and in those DAT and DPD patients who had the impaired TCD finding before the AZT test (p<0.01). Conclusion: Testing of the cerebral vasoreactivity can clarify the hemodynamic origin of dementia, indicating the basic different pathogeneity among various types of dementia and, therefore, predict the progression and the prognosis of disease.",
keywords = "Cerebral vasoreactivity, Dementia of Alzheimer's type, Parkinson's disease, Transcranial Doppler (TCD), Vascular dementia",
author = "Tatjana Rundek and V. Demarin and G. Savin",
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T1 - Impairment of cerebral vasoreactivity (CVR) in multiinfarct dementia (MID), dementia of Alzheimer's type (DAT), and dementia in Parkinson's disease (DPD)

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AU - Demarin, V.

AU - Savin, G.

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N2 - Background and purpose: The impaired cerebral vasoreactivity (CVT) occurs in severe dementia and may significantly reduce survival. In order to analyze the range of CVR in dementia we analyzed 30 patients with multi-infarct dementia (MID), 45 with dementia of Alzheimer's type (DAT), and 20 patients with dementia in Parkinson's disease (DPD). Methods: All patients fulfilled the criteria of DSM-III-R, NINDS-AIREN and NINCDS-ADRDA classification for dementia. Folstein-Mini-Mental Scale (FMMS) was used as a measure of the cognitive impairment and Hachinski ischemic score to distinguish vascular dementia. In all the patients we performed brain CT, Color Doppler Flow Imaging of the carotid and vertebral arteries and a battery of psychological rating scales and tests. Cerebral vasoreactivity was assessed by measuring the changes of blood now velocities with Transcranial Doppler after administration of acetazolamide (AZT). Results: The results showed the impairment of blood flow velocities in the Willis' circle in all MID patients before AZT stimulation, in 49% with DAT, and 20% with DPD. After the AZT stimulation the reduced CVR was observed in MID patients with the moderate and severe mental deterioration, and in those DAT and DPD patients who had the impaired TCD finding before the AZT test (p<0.01). Conclusion: Testing of the cerebral vasoreactivity can clarify the hemodynamic origin of dementia, indicating the basic different pathogeneity among various types of dementia and, therefore, predict the progression and the prognosis of disease.

AB - Background and purpose: The impaired cerebral vasoreactivity (CVT) occurs in severe dementia and may significantly reduce survival. In order to analyze the range of CVR in dementia we analyzed 30 patients with multi-infarct dementia (MID), 45 with dementia of Alzheimer's type (DAT), and 20 patients with dementia in Parkinson's disease (DPD). Methods: All patients fulfilled the criteria of DSM-III-R, NINDS-AIREN and NINCDS-ADRDA classification for dementia. Folstein-Mini-Mental Scale (FMMS) was used as a measure of the cognitive impairment and Hachinski ischemic score to distinguish vascular dementia. In all the patients we performed brain CT, Color Doppler Flow Imaging of the carotid and vertebral arteries and a battery of psychological rating scales and tests. Cerebral vasoreactivity was assessed by measuring the changes of blood now velocities with Transcranial Doppler after administration of acetazolamide (AZT). Results: The results showed the impairment of blood flow velocities in the Willis' circle in all MID patients before AZT stimulation, in 49% with DAT, and 20% with DPD. After the AZT stimulation the reduced CVR was observed in MID patients with the moderate and severe mental deterioration, and in those DAT and DPD patients who had the impaired TCD finding before the AZT test (p<0.01). Conclusion: Testing of the cerebral vasoreactivity can clarify the hemodynamic origin of dementia, indicating the basic different pathogeneity among various types of dementia and, therefore, predict the progression and the prognosis of disease.

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