Impaired Vibratory Perception and Diabetic Foot Ulceration

A. J.M. Boulton, D. B. Kubrusly, J. H. Bowker, M. T. Gadia, L. Quintero, D. M. Becker, J. S. Skyler, J. M. Sosenko

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


We have studied risk factors for diabetic foot ulceration by comparing diabetic patients who had active foot ulcers (n = 86) with diabetic patients who had no history of foot ulcers (n = 49). Whereas there was a strong association of diabetic foot ulceration with abnormal vibratory perception (Odds Ratio = 10.77; p<0.001), which increased with worsening vibratory perception), there was little association with abnormality of the ankle-pressure index (Odds Ratio = 2.84, p = n.s.). Although foot ulceration and limited joint mobility were associated (Odds Ratio = 3,57, p<0.001), this relation was not significant when allowances for abnormal vibratory perception and diabetes duration were made. These data suggest that sensory neuropathy is of greater aetiological importance than peripheral vascular disease in the development of diabetic foot ulceration. The measurement of the vibratory perception threshold is clinically useful in identifying those diabetic patients at high risk of foot ulceration.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalDiabetic Medicine
Issue number4
StatePublished - Jan 1 1986


  • Diabetes
  • Foot ulcers
  • Neuropathy
  • Peripheral vascular disease Limited joint mobility

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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