Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?

Scott D. Siegel, Michael H. Antoni, Mary Ann Fletcher, Kevin Maher, Mary Catherine Segota, Nancy Klimas

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Objective: The diagnostic criteria of chronic fatigue syndrome (CFS) define a heterogeneous population composed of several subgroups. Past efforts to identify subgroup markers have met with mixed success. This study was designed to examine natural killer cell activity (NKCA) as a potential subgroup marker by comparing the clinical presentations of CFS patients with and without clinically reduced NKCA. Methods: Forty-one female CFS patients were classified into having either low or normal NKCA levels. These subgroups were then compared on objective measures of cognitive functioning and subjective assessments of fatigue, vigor, cognitive impairment, and daytime dysfunction. Results: Relative to CFS patients in the normal-NKCA subgroup, low-NKCA patients reported less vigor, more daytime dysfunction, and more cognitive impairment. In addition, low-NKCA patients performed less on objective measures of cognitive functioning relative to normal-NKCA patients. Conclusions: The results are offered as preliminary evidence in support of using NKCA as an immunological subgroup marker in CFS. Findings are also discussed in terms of known associations between dysregulated immune functions, somatic symptoms, and psychological stress.

Original languageEnglish (US)
Pages (from-to)559-566
Number of pages8
JournalJournal of Psychosomatic Research
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2006

Keywords

  • Chronic fatigue syndrome
  • Natural killer cell activity
  • Sickness behavior
  • Subgroups

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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