Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection

G. Shor-Posner, D. Feaster, N. T. Blaney, H. Rocca, E. Mantero-Atienza, J. Szapocznik, C. Eisdorfer, K. Goodkin, M. K. Baum

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Abstract

Objective: Inadequate vitamin B6 status has been associated with altered neuropsychiatric function, possibly through its effect on the metabolism of neurotransmitters, including serotonin (5-HT). The present eighteen month longitudinal study evaluated the relationship between vitamin B6 status and psychological distress in HIV-1 infected individuals, controlling for the influence of negative life events, social support and coping style. Method: Biochemical measurements of nutritional status, and dietary intake evaluations were obtained in HIV-1 seropositive homosexual men, (at baseline: CDC Stages II and III, n = 70; Stage IVA, IVC2 n = 18) at six month intervals. Alterations in nutrient status (e.g., vitamin B6 adequate to inadequate; inadequate to adequate), were compared with changes in psychological distress, measured by the Profile of Mood States, using a multiple regression analysis. Results: A significant decline in psychological distress was demonstrated with normalization of vitamin B6 status from inadequate to adequate status (p < 0.02). A decrease in psychological distress was also observed with increased tryptophan intake in subjects who were vitamin B6 adequate (p < 0.02). Conclusions: Significant effects for the nutritional variables remained even when negative life event stressors, social support, and coping style were controlled, suggesting that vitamin B6 status may be an important co-factor in determining level of psychological distress over time in HIV-1 infected individuals.

Original languageEnglish (US)
Pages (from-to)209-222
Number of pages14
JournalInternational Journal of Psychiatry in Medicine
Volume24
Issue number3
StatePublished - Dec 1 1994

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ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Shor-Posner, G., Feaster, D., Blaney, N. T., Rocca, H., Mantero-Atienza, E., Szapocznik, J., Eisdorfer, C., Goodkin, K., & Baum, M. K. (1994). Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection. International Journal of Psychiatry in Medicine, 24(3), 209-222.