Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection

G. Shor-Posner, Daniel J Feaster, N. T. Blaney, H. Rocca, E. Mantero-Atienza, Jose Szapocznik, C. Eisdorfer, K. Goodkin, M. K. Baum

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Inadequate vitamin B6 status has been associated with altered neuropsychiatric function, possibly through its effect on the metabolism of neurotransmitters, including serotonin (5-HT). The present eighteen month longitudinal study evaluated the relationship between vitamin B6 status and psychological distress in HIV-1 infected individuals, controlling for the influence of negative life events, social support and coping style. Method: Biochemical measurements of nutritional status, and dietary intake evaluations were obtained in HIV-1 seropositive homosexual men, (at baseline: CDC Stages II and III, n = 70; Stage IVA, IVC2 n = 18) at six month intervals. Alterations in nutrient status (e.g., vitamin B6 adequate to inadequate; inadequate to adequate), were compared with changes in psychological distress, measured by the Profile of Mood States, using a multiple regression analysis. Results: A significant decline in psychological distress was demonstrated with normalization of vitamin B6 status from inadequate to adequate status (p < 0.02). A decrease in psychological distress was also observed with increased tryptophan intake in subjects who were vitamin B6 adequate (p < 0.02). Conclusions: Significant effects for the nutritional variables remained even when negative life event stressors, social support, and coping style were controlled, suggesting that vitamin B6 status may be an important co-factor in determining level of psychological distress over time in HIV-1 infected individuals.

Original languageEnglish
Pages (from-to)209-222
Number of pages14
JournalInternational Journal of Psychiatry in Medicine
Volume24
Issue number3
StatePublished - Dec 1 1994

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Vitamin B 6
HIV Infections
Longitudinal Studies
HIV-1
Psychology
Social Support
Serotonin
Centers for Disease Control and Prevention (U.S.)
Nutritional Status
Tryptophan
Neurotransmitter Agents
Regression Analysis
Food

ASJC Scopus subject areas

  • Psychiatry and Mental health

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Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection. / Shor-Posner, G.; Feaster, Daniel J; Blaney, N. T.; Rocca, H.; Mantero-Atienza, E.; Szapocznik, Jose; Eisdorfer, C.; Goodkin, K.; Baum, M. K.

In: International Journal of Psychiatry in Medicine, Vol. 24, No. 3, 01.12.1994, p. 209-222.

Research output: Contribution to journalArticle

Shor-Posner, G, Feaster, DJ, Blaney, NT, Rocca, H, Mantero-Atienza, E, Szapocznik, J, Eisdorfer, C, Goodkin, K & Baum, MK 1994, 'Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection', International Journal of Psychiatry in Medicine, vol. 24, no. 3, pp. 209-222.
Shor-Posner, G. ; Feaster, Daniel J ; Blaney, N. T. ; Rocca, H. ; Mantero-Atienza, E. ; Szapocznik, Jose ; Eisdorfer, C. ; Goodkin, K. ; Baum, M. K. / Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection. In: International Journal of Psychiatry in Medicine. 1994 ; Vol. 24, No. 3. pp. 209-222.
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