Impact of prenatal cocaine exposure on child behavior problems through school age

Henrietta S. Bada, Abhik Das, Charles R Bauer, Seetha Shankaran, Barry Lester, Linda LaGasse, Jane Hammond, Linda L. Wright, Rosemary Higgins

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

OBJECTIVE. We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS. The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS. High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS. Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes.

Original languageEnglish
JournalPediatrics
Volume119
Issue number2
DOIs
StatePublished - Feb 1 2007

Fingerprint

Child Behavior
Cocaine
Caregivers
Domestic Violence
Tobacco
Alcohols
Mothers
Meconium
Checklist
Gestational Age
Longitudinal Studies
Life Style
Linear Models
Cohort Studies
Demography
Depression
Psychology
Problem Behavior

Keywords

  • Alcohol
  • Child behavior
  • Cocaine
  • Prenatal exposure
  • Tobacco

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bada, H. S., Das, A., Bauer, C. R., Shankaran, S., Lester, B., LaGasse, L., ... Higgins, R. (2007). Impact of prenatal cocaine exposure on child behavior problems through school age. Pediatrics, 119(2). https://doi.org/10.1542/peds.2006-1404

Impact of prenatal cocaine exposure on child behavior problems through school age. / Bada, Henrietta S.; Das, Abhik; Bauer, Charles R; Shankaran, Seetha; Lester, Barry; LaGasse, Linda; Hammond, Jane; Wright, Linda L.; Higgins, Rosemary.

In: Pediatrics, Vol. 119, No. 2, 01.02.2007.

Research output: Contribution to journalArticle

Bada, HS, Das, A, Bauer, CR, Shankaran, S, Lester, B, LaGasse, L, Hammond, J, Wright, LL & Higgins, R 2007, 'Impact of prenatal cocaine exposure on child behavior problems through school age', Pediatrics, vol. 119, no. 2. https://doi.org/10.1542/peds.2006-1404
Bada HS, Das A, Bauer CR, Shankaran S, Lester B, LaGasse L et al. Impact of prenatal cocaine exposure on child behavior problems through school age. Pediatrics. 2007 Feb 1;119(2). https://doi.org/10.1542/peds.2006-1404
Bada, Henrietta S. ; Das, Abhik ; Bauer, Charles R ; Shankaran, Seetha ; Lester, Barry ; LaGasse, Linda ; Hammond, Jane ; Wright, Linda L. ; Higgins, Rosemary. / Impact of prenatal cocaine exposure on child behavior problems through school age. In: Pediatrics. 2007 ; Vol. 119, No. 2.
@article{e46ef3d78564404e878491f9c9babcaf,
title = "Impact of prenatal cocaine exposure on child behavior problems through school age",
abstract = "OBJECTIVE. We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS. The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS. High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS. Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes.",
keywords = "Alcohol, Child behavior, Cocaine, Prenatal exposure, Tobacco",
author = "Bada, {Henrietta S.} and Abhik Das and Bauer, {Charles R} and Seetha Shankaran and Barry Lester and Linda LaGasse and Jane Hammond and Wright, {Linda L.} and Rosemary Higgins",
year = "2007",
month = "2",
day = "1",
doi = "10.1542/peds.2006-1404",
language = "English",
volume = "119",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "2",

}

TY - JOUR

T1 - Impact of prenatal cocaine exposure on child behavior problems through school age

AU - Bada, Henrietta S.

AU - Das, Abhik

AU - Bauer, Charles R

AU - Shankaran, Seetha

AU - Lester, Barry

AU - LaGasse, Linda

AU - Hammond, Jane

AU - Wright, Linda L.

AU - Higgins, Rosemary

PY - 2007/2/1

Y1 - 2007/2/1

N2 - OBJECTIVE. We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS. The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS. High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS. Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes.

AB - OBJECTIVE. We examined the trajectory of childhood behavior problems after prenatal cocaine exposure. METHODS. The Maternal Lifestyle Study, a longitudinal cohort study, enrolled children between 1993 and 1995 at 4 centers. Prenatal cocaine exposure was determined from mothers who admitted use and/or meconium results. Exposed children were matched with a group of nonexposed children within site and by gestational age, gender, race, and ethnicity. The study began at the 1-month corrected age with a total of 1388 children enrolled. A total of 1056 were assessed for internalizing, externalizing, and total behavior problems at ages 3, 5, and 7 years using the Child Behavior Checklist. Longitudinal hierarchical linear models were used to determine the effect of prenatal cocaine exposure on behavior problem trajectories while controlling for other prenatal exposures; time-varying covariates, including ongoing caregiver use of legal and illegal substances; demographic factors; family violence; and caregiver psychological distress. RESULTS. High prenatal cocaine exposure was associated with the trajectory of internalizing, externalizing, and total behavior problems; these effects were independent of and less than the significant combined effect of prenatal and postnatal tobacco and alcohol exposures. Caregiver depression and family violence had independent negative influence on all behavior outcomes. CONCLUSIONS. Prenatal cocaine exposure has a negative impact on the trajectories of childhood behavior outcomes. When they co-occur with prenatal cocaine exposure, prenatal and postnatal tobacco and alcohol exposures have added negative effects on behavior outcomes.

KW - Alcohol

KW - Child behavior

KW - Cocaine

KW - Prenatal exposure

KW - Tobacco

UR - http://www.scopus.com/inward/record.url?scp=33947104549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947104549&partnerID=8YFLogxK

U2 - 10.1542/peds.2006-1404

DO - 10.1542/peds.2006-1404

M3 - Article

C2 - 17272597

AN - SCOPUS:33947104549

VL - 119

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 2

ER -