Impact of prenatal cocaine exposure on attention and response inhibition as assessed by continuous performance tests

Veronica H. Accornero, Alfred J. Amado, Connie E. Morrow, Lihua Xue, James C. Anthony, Emmalee S. Bandstra

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

OBJECTIVE: This study examined the influence of prenatal cocaine exposure on attention and response inhibition measured by continuous performance tests (CPTs) at ages 5 and 7 years. METHODS: The baseline sample consisted of 253 cocaine-exposed and 223 non-cocaine-exposed children enrolled prospectively at birth and assessed comprehensively through age 7 years in the longitudinal Miami Prenatal Cocaine Study. This report includes a subsample of 415 children (219 cocaine-exposed, 196 non-cocaine-exposed) who completed at least one CPT assessment at ages 5 and/or 7 years. Prenatal cocaine exposure was measured by maternal self-report and maternal and infant bioassays. Deficits in attention and response inhibition are estimated in relation to prenatal cocaine exposure using generalized estimating equations within the general linear model. RESULTS: Results indicate cocaine-associated increases in omission errors at ages 5 and 7 as well as increases in response times for target tasks (i.e., slower reaction times) and decreased consistency in performance at age 7. There were no demonstrable cocaine-associated deficits in commission errors. Estimates did not change markedly with statistical adjustment for selected prenatal and postnatal covariates. CONCLUSION: Evidence supports cocaine-associated deficits in attention processing through age 7 years.

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalJournal of Developmental and Behavioral Pediatrics
Volume28
Issue number3
DOIs
StatePublished - Jun 2007

Keywords

  • Continuous performance test
  • Prenatal cocaine exposure
  • Response inhibition
  • Sustained attention

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Behavioral Neuroscience
  • Psychology(all)
  • Developmental and Educational Psychology

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