Impact of nutritional factors on incident kidney stone formation

A report from the WHI OS

Mathew D. Sorensen, Arnold J. Kahn, Alex P. Reiner, Timothy Y. Tseng, James M. Shikany, Robert B. Wallace, Thomas Chi, Jean Wactawski-Wende, Rebecca D. Jackson, Mary Jo O'Sullivan, Natalia Sadetsky, Marshall L. Stoller

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Purpose: Increased fluid intake, and decreased dietary sodium and animal protein intake are thought to reduce the risk of kidney stones but the role of calcium intake is controversial. We evaluated the relationship between dietary factors and incident kidney stone formation. Materials and Methods: Secondary analysis was done of 78,293 women from the prospective WHI OS (Women's Health Initiative Observational Study) with no history of nephrolithiasis who completed the validated food frequency questionnaire. Multivariate logistic regression was used to determine demographic and dietary factors, and supplement use independently associated with incident kidney stones. Results: Overall 1,952 women (2.5%) reported an incident kidney stone in 573,575 person-years of followup. The risk of incident kidney stones was decreased by 5% to 28% (p = 0.01) with higher dietary calcium intake and by 13% to 31% (p = 0.002) with higher water intake after adjusting for nephrolithiasis risk factors. Conversely higher dietary sodium intake increased the risk of nephrolithiasis by 11% to 61% (p <0.001) after adjustment with the most pronounced effect in women with the highest intake. Higher body mass index independently increased the risk of incident nephrolithiasis (adjusted OR 1.19-2.01, p <0.001). Animal protein intake was not associated with nephrolithiasis on multivariate analysis. Conclusions: This study adds to the growing evidence underscoring the importance of maintaining adequate fluid and dietary calcium intake. Greater dietary calcium intake significantly decreased the risk of incident kidney stones. In contrast, excess sodium intake increased the risk of incident nephrolithiasis, especially in women with the highest intake. Animal protein intake was not independently associated with nephrolithiasis.

Original languageEnglish
Pages (from-to)1645-1649
Number of pages5
JournalJournal of Urology
Volume187
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

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Nephrolithiasis
Kidney Calculi
Dietary Calcium
Dietary Sodium
Proteins
Women's Health
Dietary Supplements
Drinking
Observational Studies
Body Mass Index
Multivariate Analysis
Logistic Models
Sodium
Demography
Calcium
Food

Keywords

  • calcium, dietary
  • kidney
  • kidney calculi
  • nutrition disorders
  • sodium, dietary

ASJC Scopus subject areas

  • Urology

Cite this

Sorensen, M. D., Kahn, A. J., Reiner, A. P., Tseng, T. Y., Shikany, J. M., Wallace, R. B., ... Stoller, M. L. (2012). Impact of nutritional factors on incident kidney stone formation: A report from the WHI OS. Journal of Urology, 187(5), 1645-1649. https://doi.org/10.1016/j.juro.2011.12.077

Impact of nutritional factors on incident kidney stone formation : A report from the WHI OS. / Sorensen, Mathew D.; Kahn, Arnold J.; Reiner, Alex P.; Tseng, Timothy Y.; Shikany, James M.; Wallace, Robert B.; Chi, Thomas; Wactawski-Wende, Jean; Jackson, Rebecca D.; O'Sullivan, Mary Jo; Sadetsky, Natalia; Stoller, Marshall L.

In: Journal of Urology, Vol. 187, No. 5, 01.05.2012, p. 1645-1649.

Research output: Contribution to journalArticle

Sorensen, MD, Kahn, AJ, Reiner, AP, Tseng, TY, Shikany, JM, Wallace, RB, Chi, T, Wactawski-Wende, J, Jackson, RD, O'Sullivan, MJ, Sadetsky, N & Stoller, ML 2012, 'Impact of nutritional factors on incident kidney stone formation: A report from the WHI OS', Journal of Urology, vol. 187, no. 5, pp. 1645-1649. https://doi.org/10.1016/j.juro.2011.12.077
Sorensen MD, Kahn AJ, Reiner AP, Tseng TY, Shikany JM, Wallace RB et al. Impact of nutritional factors on incident kidney stone formation: A report from the WHI OS. Journal of Urology. 2012 May 1;187(5):1645-1649. https://doi.org/10.1016/j.juro.2011.12.077
Sorensen, Mathew D. ; Kahn, Arnold J. ; Reiner, Alex P. ; Tseng, Timothy Y. ; Shikany, James M. ; Wallace, Robert B. ; Chi, Thomas ; Wactawski-Wende, Jean ; Jackson, Rebecca D. ; O'Sullivan, Mary Jo ; Sadetsky, Natalia ; Stoller, Marshall L. / Impact of nutritional factors on incident kidney stone formation : A report from the WHI OS. In: Journal of Urology. 2012 ; Vol. 187, No. 5. pp. 1645-1649.
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AU - Shikany, James M.

AU - Wallace, Robert B.

AU - Chi, Thomas

AU - Wactawski-Wende, Jean

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