Impact of MHC class I diversity on immune control of immunodeficiency virus replication

Philip J.R. Goulder, David I. Watkins

Research output: Contribution to journalReview article

337 Scopus citations

Abstract

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8+ T-cell responses. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future.

Original languageEnglish (US)
Pages (from-to)619-630
Number of pages12
JournalNature Reviews Immunology
Volume8
Issue number8
DOIs
StatePublished - Aug 1 2008

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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