Impact of eyelid laxity on symptoms and signs of dry eye disease

Priyanka Chhadva, Allison L. McClellan, Chrisfouad R. Alabiad, William J. Feuer, Hatim Batawi, Anat Galor

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose: To study the relationship between eyelid laxity and ocular symptoms and signs of dry eye (DE). Methods: A total of 138 patients with normal external anatomy were prospectively recruited from a Veterans Administration hospital. Symptoms (via the Dry Eye Questionnaire 5 and Ocular Surface Disease Index) and signs of DE were assessed along with presence or absence of eyelid laxity. Results: It was observed that 71% of participants (n = 98) had clinical evidence of eyelid laxity (upper and/or lower) compared with 29% (n = 40) with no eyelid laxity. Individuals with eyelid laxity were older (67 ± 10 vs. 55 ± 8 years without laxity, P < 0.005) and more frequently male (76% of males had laxity vs. 18% females, P < 0.005). Patients with eyelid laxity had increased symptoms and signs of DE compared with their counterparts without laxity including ocular pain described as grittiness (63% vs. 45%, P = 0.049), decreased tear breakup time (8.6 ± 3 vs. 10.3 ± 4 seconds, P = 0.02), increased corneal staining (2.5 ± 3 vs. 1 ± 2, P = 0.002), decreased Schirmer score (1466 vs. 1767 mm, P = 0.01), increased meibomian gland drop out (2 ± 1 vs. 0.8 ± 0.8, P < 0.005), increased eyelid vascularity (0.8 ± 0.8 vs. 0.2 ± 0.5, P < 0.005), and more abnormal meibum quality (2 ± 1.3 vs. 1.4 ± 1.2, P = 0.02). In a multivariable analysis considering both signs of DE and laxity, lower eyelid laxity remained significantly associated with ocular surface disease index scores, suggesting a direct effect of laxity on symptoms of DE. Conclusions: The presence of eyelid laxity associates with abnormal tear parameters compared with the absence of eyelid laxity. Based on these data, it is important for clinicians to test for eyelid laxity in patients with symptoms and/or signs of DE.

Original languageEnglish (US)
Pages (from-to)531-535
Number of pages5
Issue number4
StatePublished - Mar 4 2016


  • Dry eye
  • Dry eye signs
  • Dry eye symptoms
  • Eyelid laxity
  • Floppy eyelid

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Impact of eyelid laxity on symptoms and signs of dry eye disease'. Together they form a unique fingerprint.

Cite this