Abstract
Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ERα deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ERα deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ERβ had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ERα, but not ERβ, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice.
| Original language | English |
|---|---|
| Pages (from-to) | 259-268 |
| Number of pages | 10 |
| Journal | Clinical Immunology |
| Volume | 128 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2008 |
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Keywords
- Autoimmunity
- Estrogen receptors
- Lupus
- Renal disease
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse. / Svenson, John L.; EuDaly, Jackie; Ruiz, Phillip; Korach, Kenneth S.; Gilkeson, Gary S.
In: Clinical Immunology, Vol. 128, No. 2, 01.08.2008, p. 259-268.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse
AU - Svenson, John L.
AU - EuDaly, Jackie
AU - Ruiz, Phillip
AU - Korach, Kenneth S.
AU - Gilkeson, Gary S.
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ERα deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ERα deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ERβ had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ERα, but not ERβ, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice.
AB - Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ERα deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ERα deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ERβ had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ERα, but not ERβ, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice.
KW - Autoimmunity
KW - Estrogen receptors
KW - Lupus
KW - Renal disease
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UR - http://www.scopus.com/inward/citedby.url?scp=46949091514&partnerID=8YFLogxK
U2 - 10.1016/j.clim.2008.03.508
DO - 10.1016/j.clim.2008.03.508
M3 - Article
C2 - 18514033
AN - SCOPUS:46949091514
VL - 128
SP - 259
EP - 268
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 2
ER -