Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse

John L. Svenson, Jackie EuDaly, Phillip Ruiz, Kenneth S. Korach, Gary S. Gilkeson

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ERα deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ERα deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ERβ had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ERα, but not ERβ, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice.

Original languageEnglish
Pages (from-to)259-268
Number of pages10
JournalClinical Immunology
Volume128
Issue number2
DOIs
StatePublished - Aug 1 2008

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Keywords

  • Autoimmunity
  • Estrogen receptors
  • Lupus
  • Renal disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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