Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease

the NET PD LS1 investigators

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.

Original languageEnglish (US)
Pages (from-to)371-378
Number of pages8
JournalMovement Disorders Clinical Practice
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2015

Fingerprint

Parkinson Disease
Depression
Equipment and Supplies
Disease Progression
Multivariate Analysis
National Institute of Neurological Disorders and Stroke
Quality of Life

Keywords

  • beck depression inventory
  • depression
  • NET-PD
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease. / the NET PD LS1 investigators.

In: Movement Disorders Clinical Practice, Vol. 2, No. 4, 01.12.2015, p. 371-378.

Research output: Contribution to journalArticle

@article{e6faf0f9102344b39017552887df7621,
title = "Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease",
abstract = "Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8{\%} of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.",
keywords = "beck depression inventory, depression, NET-PD, Parkinson's disease",
author = "{the NET PD LS1 investigators} and Danny Bega and Sheng Luo and Hubert Fernandez and Kelvin Chou and Michael Aminoff and Sotirios Parashos and Harrison Walker and Russell, {David S.} and Christine, {Chadwick W.} and Rohit Dhall and Carlos Singer and Ivan Bodis-Wollner and Robert Hamill and Daniel Truong and Zoltan Mari and Sofya Glazmann and Meilin Huang and Emily Houston and Tanya Simuni",
year = "2015",
month = "12",
day = "1",
doi = "10.1002/mdc3.12205",
language = "English (US)",
volume = "2",
pages = "371--378",
journal = "Movement Disorders Clinical Practice",
issn = "2330-1619",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

TY - JOUR

T1 - Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease

AU - the NET PD LS1 investigators

AU - Bega, Danny

AU - Luo, Sheng

AU - Fernandez, Hubert

AU - Chou, Kelvin

AU - Aminoff, Michael

AU - Parashos, Sotirios

AU - Walker, Harrison

AU - Russell, David S.

AU - Christine, Chadwick W.

AU - Dhall, Rohit

AU - Singer, Carlos

AU - Bodis-Wollner, Ivan

AU - Hamill, Robert

AU - Truong, Daniel

AU - Mari, Zoltan

AU - Glazmann, Sofya

AU - Huang, Meilin

AU - Houston, Emily

AU - Simuni, Tanya

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.

AB - Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.

KW - beck depression inventory

KW - depression

KW - NET-PD

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=85034707807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034707807&partnerID=8YFLogxK

U2 - 10.1002/mdc3.12205

DO - 10.1002/mdc3.12205

M3 - Article

AN - SCOPUS:85034707807

VL - 2

SP - 371

EP - 378

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

SN - 2330-1619

IS - 4

ER -