Abstract
Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 371-378 |
| Number of pages | 8 |
| Journal | Movement Disorders Clinical Practice |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2015 |
Fingerprint
Keywords
- beck depression inventory
- depression
- NET-PD
- Parkinson's disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease. / the NET PD LS1 investigators.
In: Movement Disorders Clinical Practice, Vol. 2, No. 4, 01.12.2015, p. 371-378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease
AU - the NET PD LS1 investigators
AU - Bega, Danny
AU - Luo, Sheng
AU - Fernandez, Hubert
AU - Chou, Kelvin
AU - Aminoff, Michael
AU - Parashos, Sotirios
AU - Walker, Harrison
AU - Russell, David S.
AU - Christine, Chadwick W.
AU - Dhall, Rohit
AU - Singer, Carlos
AU - Bodis-Wollner, Ivan
AU - Hamill, Robert
AU - Truong, Daniel
AU - Mari, Zoltan
AU - Glazmann, Sofya
AU - Huang, Meilin
AU - Houston, Emily
AU - Simuni, Tanya
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.
AB - Background: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. Objective: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. Methods: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. Results: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. Conclusions: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.
KW - beck depression inventory
KW - depression
KW - NET-PD
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=85034707807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034707807&partnerID=8YFLogxK
U2 - 10.1002/mdc3.12205
DO - 10.1002/mdc3.12205
M3 - Article
AN - SCOPUS:85034707807
VL - 2
SP - 371
EP - 378
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
SN - 2330-1619
IS - 4
ER -