Impact of contact lens group on antifungal efficacy of multipurpose disinfecting contact lens solutions

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16 Citations (Scopus)

Abstract

PURPOSE. To evaluate and compare the in vitro effectiveness of multipurpose contact lens solutions (MPDS) to inhibit fungal colonization of Food and Drug Administration (FDA) contact lens groups. METHODS. Contact lenses from FDA groups I (low water content, nonionic), II (high water content, nonionic), III (low water content, ionic), and IV (high water content, ionic) were placed in sterile contact lens cases with 2 mL of ReNu MultiPlus, ReNu with MoistureLoc, or OPTI-FREE RepleniSH. Each contact lens-multipurpose solution combination was challenged with 0.1 mL of 10 colony-forming units/mL of Fusarium oxysporum and incubated at room temperature. Contact lenses and aliquots from phosphate-buffered saline rinse solutions, multipurpose solutions in cases, and lens cases were sampled at 24, 48, and 72 hours, plated on Sabouraud's agar, incubated at room temperature, and observed for growth (i.e., adhesion) for 1 to 7 days. RESULTS. Used multipurpose contact lens solutions met or exceeded the 1-log reduction requirement of the FDA stand-alone test. Viable fungal colonies were recovered from group II lenses after 24 hours of storage in all three multipurpose solutions. Colonization was also detected with at least one contact lens-multipurpose solution pairing from groups I, III, and IV. Fungi were not recovered from lens-solution combinations after 24 hours or from phosphate-buffered saline solutions or lens cases at any period. CONCLUSIONS. Antifungal activity of contaminated multipurpose solutions may be insufficient to prevent fungal colonization of contact lens materials despite meeting or exceeding the FDA stand-alone test criteria. Colonized lens may increase the risk of fungal keratitis.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalEye and Contact Lens
Volume34
Issue number3
DOIs
StatePublished - May 1 2008

Fingerprint

Contact Lens Solutions
Contact Lenses
Lenses
United States Food and Drug Administration
Water
Sodium Chloride
Phosphates
Temperature
Keratitis
Fusarium
Agar
Fungi
Stem Cells
Growth

Keywords

  • Colonization
  • Contact lens
  • Fusarium oxysporum
  • Multipurpose solution

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{0596ec5845ea4474865f1dd3adbfcf37,
title = "Impact of contact lens group on antifungal efficacy of multipurpose disinfecting contact lens solutions",
abstract = "PURPOSE. To evaluate and compare the in vitro effectiveness of multipurpose contact lens solutions (MPDS) to inhibit fungal colonization of Food and Drug Administration (FDA) contact lens groups. METHODS. Contact lenses from FDA groups I (low water content, nonionic), II (high water content, nonionic), III (low water content, ionic), and IV (high water content, ionic) were placed in sterile contact lens cases with 2 mL of ReNu MultiPlus, ReNu with MoistureLoc, or OPTI-FREE RepleniSH. Each contact lens-multipurpose solution combination was challenged with 0.1 mL of 10 colony-forming units/mL of Fusarium oxysporum and incubated at room temperature. Contact lenses and aliquots from phosphate-buffered saline rinse solutions, multipurpose solutions in cases, and lens cases were sampled at 24, 48, and 72 hours, plated on Sabouraud's agar, incubated at room temperature, and observed for growth (i.e., adhesion) for 1 to 7 days. RESULTS. Used multipurpose contact lens solutions met or exceeded the 1-log reduction requirement of the FDA stand-alone test. Viable fungal colonies were recovered from group II lenses after 24 hours of storage in all three multipurpose solutions. Colonization was also detected with at least one contact lens-multipurpose solution pairing from groups I, III, and IV. Fungi were not recovered from lens-solution combinations after 24 hours or from phosphate-buffered saline solutions or lens cases at any period. CONCLUSIONS. Antifungal activity of contaminated multipurpose solutions may be insufficient to prevent fungal colonization of contact lens materials despite meeting or exceeding the FDA stand-alone test criteria. Colonized lens may increase the risk of fungal keratitis.",
keywords = "Colonization, Contact lens, Fusarium oxysporum, Multipurpose solution",
author = "Takeshi Ide and Darlene Miller and Alfonso, {Eduardo C} and Terrence O'Brien",
year = "2008",
month = "5",
day = "1",
doi = "10.1097/ICL.0b013e31815788a6",
language = "English",
volume = "34",
pages = "151--159",
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TY - JOUR

T1 - Impact of contact lens group on antifungal efficacy of multipurpose disinfecting contact lens solutions

AU - Ide, Takeshi

AU - Miller, Darlene

AU - Alfonso, Eduardo C

AU - O'Brien, Terrence

PY - 2008/5/1

Y1 - 2008/5/1

N2 - PURPOSE. To evaluate and compare the in vitro effectiveness of multipurpose contact lens solutions (MPDS) to inhibit fungal colonization of Food and Drug Administration (FDA) contact lens groups. METHODS. Contact lenses from FDA groups I (low water content, nonionic), II (high water content, nonionic), III (low water content, ionic), and IV (high water content, ionic) were placed in sterile contact lens cases with 2 mL of ReNu MultiPlus, ReNu with MoistureLoc, or OPTI-FREE RepleniSH. Each contact lens-multipurpose solution combination was challenged with 0.1 mL of 10 colony-forming units/mL of Fusarium oxysporum and incubated at room temperature. Contact lenses and aliquots from phosphate-buffered saline rinse solutions, multipurpose solutions in cases, and lens cases were sampled at 24, 48, and 72 hours, plated on Sabouraud's agar, incubated at room temperature, and observed for growth (i.e., adhesion) for 1 to 7 days. RESULTS. Used multipurpose contact lens solutions met or exceeded the 1-log reduction requirement of the FDA stand-alone test. Viable fungal colonies were recovered from group II lenses after 24 hours of storage in all three multipurpose solutions. Colonization was also detected with at least one contact lens-multipurpose solution pairing from groups I, III, and IV. Fungi were not recovered from lens-solution combinations after 24 hours or from phosphate-buffered saline solutions or lens cases at any period. CONCLUSIONS. Antifungal activity of contaminated multipurpose solutions may be insufficient to prevent fungal colonization of contact lens materials despite meeting or exceeding the FDA stand-alone test criteria. Colonized lens may increase the risk of fungal keratitis.

AB - PURPOSE. To evaluate and compare the in vitro effectiveness of multipurpose contact lens solutions (MPDS) to inhibit fungal colonization of Food and Drug Administration (FDA) contact lens groups. METHODS. Contact lenses from FDA groups I (low water content, nonionic), II (high water content, nonionic), III (low water content, ionic), and IV (high water content, ionic) were placed in sterile contact lens cases with 2 mL of ReNu MultiPlus, ReNu with MoistureLoc, or OPTI-FREE RepleniSH. Each contact lens-multipurpose solution combination was challenged with 0.1 mL of 10 colony-forming units/mL of Fusarium oxysporum and incubated at room temperature. Contact lenses and aliquots from phosphate-buffered saline rinse solutions, multipurpose solutions in cases, and lens cases were sampled at 24, 48, and 72 hours, plated on Sabouraud's agar, incubated at room temperature, and observed for growth (i.e., adhesion) for 1 to 7 days. RESULTS. Used multipurpose contact lens solutions met or exceeded the 1-log reduction requirement of the FDA stand-alone test. Viable fungal colonies were recovered from group II lenses after 24 hours of storage in all three multipurpose solutions. Colonization was also detected with at least one contact lens-multipurpose solution pairing from groups I, III, and IV. Fungi were not recovered from lens-solution combinations after 24 hours or from phosphate-buffered saline solutions or lens cases at any period. CONCLUSIONS. Antifungal activity of contaminated multipurpose solutions may be insufficient to prevent fungal colonization of contact lens materials despite meeting or exceeding the FDA stand-alone test criteria. Colonized lens may increase the risk of fungal keratitis.

KW - Colonization

KW - Contact lens

KW - Fusarium oxysporum

KW - Multipurpose solution

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DO - 10.1097/ICL.0b013e31815788a6

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VL - 34

SP - 151

EP - 159

JO - Eye and Contact Lense

JF - Eye and Contact Lense

SN - 1542-2321

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