Impact of Abnormal Sperm Morphology on Live Birth Rates Following Intrauterine Insemination

Premal Patel, Robert Carrasquillo, Vinayak Madhusoodanan, Simon Dadoun, Amir Patel, Nicole Smith, Inea Collazo, Taylor Kohn, Ranjith Ramasamy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

PURPOSE: We evaluated the live birth rate and the prevalence of congenital anomalies in couples undergoing intrauterine insemination with abnormal sperm morphology (less than 4% normal forms). MATERIALS AND METHODS: We retrospectively reviewed intrauterine insemination outcomes from January 2012 to March 2015. Patients who were found to have an ultrasound confirmed clinical pregnancy were contacted to determine the live birth rate and the prevalence of congenital abnormalities. We used chi-square analysis to assess categorical variables and the Student t-test to assess continuous variables. Logistic regression was done to assess the odds of achieving pregnancy and the risk of spontaneous abortion while assessing female age, the total motile count and sperm morphology. RESULTS: In 984 intrauterine insemination procedures performed in a total of 501 couples we found no difference in the ultrasound clinical pregnancy rate in couples with sperm morphology less than 4% vs 4% or greater (12.3% vs 13.6%, p=0.59). We collected live birth and birth abnormality data on 95 of the 130 couples with ultrasound confirmed clinical pregnancy for a 73% response rate. We found no difference in the live birth rate or the spontaneous abortion rate after an ultrasound confirmed clinical pregnancy in couples with abnormal sperm morphology (less than 4% normal forms). There was also no increased risk of birth abnormalities for patients with abnormal sperm morphology. CONCLUSIONS: Abnormal sperm morphology impacted neither the pregnancy rate nor the live birth rate in couples undergoing intrauterine insemination. These results can be used to reassure couples who undergo intrauterine insemination that there is a minimal impact of abnormal sperm morphology on the live birth rate and the prevalence of birth abnormalities.

Original languageEnglish (US)
Pages (from-to)801-805
Number of pages5
JournalThe Journal of urology
Volume202
Issue number4
DOIs
StatePublished - Oct 1 2019

Fingerprint

Insemination
Birth Rate
Live Birth
Spermatozoa
Pregnancy
Parturition
Spontaneous Abortion
Pregnancy Rate
Sperm Count
Induced Abortion
Logistic Models
Students

Keywords

  • artificial
  • congenital abnormalities
  • insemination
  • live birth
  • teratozoospermia
  • testis

ASJC Scopus subject areas

  • Urology

Cite this

Impact of Abnormal Sperm Morphology on Live Birth Rates Following Intrauterine Insemination. / Patel, Premal; Carrasquillo, Robert; Madhusoodanan, Vinayak; Dadoun, Simon; Patel, Amir; Smith, Nicole; Collazo, Inea; Kohn, Taylor; Ramasamy, Ranjith.

In: The Journal of urology, Vol. 202, No. 4, 01.10.2019, p. 801-805.

Research output: Contribution to journalArticle

Patel, P, Carrasquillo, R, Madhusoodanan, V, Dadoun, S, Patel, A, Smith, N, Collazo, I, Kohn, T & Ramasamy, R 2019, 'Impact of Abnormal Sperm Morphology on Live Birth Rates Following Intrauterine Insemination', The Journal of urology, vol. 202, no. 4, pp. 801-805. https://doi.org/10.1097/JU.0000000000000288
Patel P, Carrasquillo R, Madhusoodanan V, Dadoun S, Patel A, Smith N et al. Impact of Abnormal Sperm Morphology on Live Birth Rates Following Intrauterine Insemination. The Journal of urology. 2019 Oct 1;202(4):801-805. https://doi.org/10.1097/JU.0000000000000288
Patel, Premal ; Carrasquillo, Robert ; Madhusoodanan, Vinayak ; Dadoun, Simon ; Patel, Amir ; Smith, Nicole ; Collazo, Inea ; Kohn, Taylor ; Ramasamy, Ranjith. / Impact of Abnormal Sperm Morphology on Live Birth Rates Following Intrauterine Insemination. In: The Journal of urology. 2019 ; Vol. 202, No. 4. pp. 801-805.
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AB - PURPOSE: We evaluated the live birth rate and the prevalence of congenital anomalies in couples undergoing intrauterine insemination with abnormal sperm morphology (less than 4% normal forms). MATERIALS AND METHODS: We retrospectively reviewed intrauterine insemination outcomes from January 2012 to March 2015. Patients who were found to have an ultrasound confirmed clinical pregnancy were contacted to determine the live birth rate and the prevalence of congenital abnormalities. We used chi-square analysis to assess categorical variables and the Student t-test to assess continuous variables. Logistic regression was done to assess the odds of achieving pregnancy and the risk of spontaneous abortion while assessing female age, the total motile count and sperm morphology. RESULTS: In 984 intrauterine insemination procedures performed in a total of 501 couples we found no difference in the ultrasound clinical pregnancy rate in couples with sperm morphology less than 4% vs 4% or greater (12.3% vs 13.6%, p=0.59). We collected live birth and birth abnormality data on 95 of the 130 couples with ultrasound confirmed clinical pregnancy for a 73% response rate. We found no difference in the live birth rate or the spontaneous abortion rate after an ultrasound confirmed clinical pregnancy in couples with abnormal sperm morphology (less than 4% normal forms). There was also no increased risk of birth abnormalities for patients with abnormal sperm morphology. CONCLUSIONS: Abnormal sperm morphology impacted neither the pregnancy rate nor the live birth rate in couples undergoing intrauterine insemination. These results can be used to reassure couples who undergo intrauterine insemination that there is a minimal impact of abnormal sperm morphology on the live birth rate and the prevalence of birth abnormalities.

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