Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1

Gail Shor-Posner, Maria Hernandez-Reif, Maria Jose Miguez, Maryann Fletcher, Noaris Quintero, Jeanette Baez, Eddy Perez-Then, Solange Soto, Rosangela Mendoza, Raquell Castillo, Guoyan Zhang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: The effectiveness of massage therapy on immune parameters was evaluated in young Dominican HIV+ children without current access to antiretroviral therapies. Methods: Eligible children, who were followed at the Robert Reid Cabral Hospital (San Domingo, Dominican Republic), were randomized to receive either massage treatment or a control/friendly visit twice weekly for 12 weeks. Blood was drawn at baseline and following the 3-month intervention for determinations of CD4, CD8, and CD56 cell counts and percentage, along with activation markers (CD25 and CD69). Results: Despite similar immune parameters at baseline in the two groups, significantly more of the control group exhibited a decline in CD4 cell count (>30%, p = 0.03), postintervention. The decrease was particularly evident in older (5-8 years) children in the control arm, who demonstrated a significant reduction in both CD4 and CD8 cell counts compared to massage-treated older children who remained stable or showed immune improvement. Additionally, a significant increase in CD4+CD25+ cells was observed over the 12-week trial in the massage-treated older children (p = 0.04) but not in the control group. In younger massage-treated children, (2-4 years old), a significant increase in natural killer cells was shown. Conclusion: Together these findings support the role for massage therapy in immune preservation in HIV+ children.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalJournal of Alternative and Complementary Medicine
Volume12
Issue number6
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

Fingerprint

Massage
HIV-1
Clinical Trials
CD4 Lymphocyte Count
Dominican Republic
HIV
Control Groups
Natural Killer Cells
Cell Count
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Complementary and alternative medicine
  • Nursing(all)

Cite this

Shor-Posner, G., Hernandez-Reif, M., Miguez, M. J., Fletcher, M., Quintero, N., Baez, J., ... Zhang, G. (2006). Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1. Journal of Alternative and Complementary Medicine, 12(6), 511-516. https://doi.org/10.1089/acm.2006.12.511

Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1. / Shor-Posner, Gail; Hernandez-Reif, Maria; Miguez, Maria Jose; Fletcher, Maryann; Quintero, Noaris; Baez, Jeanette; Perez-Then, Eddy; Soto, Solange; Mendoza, Rosangela; Castillo, Raquell; Zhang, Guoyan.

In: Journal of Alternative and Complementary Medicine, Vol. 12, No. 6, 01.07.2006, p. 511-516.

Research output: Contribution to journalArticle

Shor-Posner, G, Hernandez-Reif, M, Miguez, MJ, Fletcher, M, Quintero, N, Baez, J, Perez-Then, E, Soto, S, Mendoza, R, Castillo, R & Zhang, G 2006, 'Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1', Journal of Alternative and Complementary Medicine, vol. 12, no. 6, pp. 511-516. https://doi.org/10.1089/acm.2006.12.511
Shor-Posner, Gail ; Hernandez-Reif, Maria ; Miguez, Maria Jose ; Fletcher, Maryann ; Quintero, Noaris ; Baez, Jeanette ; Perez-Then, Eddy ; Soto, Solange ; Mendoza, Rosangela ; Castillo, Raquell ; Zhang, Guoyan. / Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1. In: Journal of Alternative and Complementary Medicine. 2006 ; Vol. 12, No. 6. pp. 511-516.
@article{6070e12dec4d48d88e374eebbff6930c,
title = "Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1",
abstract = "Purpose: The effectiveness of massage therapy on immune parameters was evaluated in young Dominican HIV+ children without current access to antiretroviral therapies. Methods: Eligible children, who were followed at the Robert Reid Cabral Hospital (San Domingo, Dominican Republic), were randomized to receive either massage treatment or a control/friendly visit twice weekly for 12 weeks. Blood was drawn at baseline and following the 3-month intervention for determinations of CD4, CD8, and CD56 cell counts and percentage, along with activation markers (CD25 and CD69). Results: Despite similar immune parameters at baseline in the two groups, significantly more of the control group exhibited a decline in CD4 cell count (>30{\%}, p = 0.03), postintervention. The decrease was particularly evident in older (5-8 years) children in the control arm, who demonstrated a significant reduction in both CD4 and CD8 cell counts compared to massage-treated older children who remained stable or showed immune improvement. Additionally, a significant increase in CD4+CD25+ cells was observed over the 12-week trial in the massage-treated older children (p = 0.04) but not in the control group. In younger massage-treated children, (2-4 years old), a significant increase in natural killer cells was shown. Conclusion: Together these findings support the role for massage therapy in immune preservation in HIV+ children.",
author = "Gail Shor-Posner and Maria Hernandez-Reif and Miguez, {Maria Jose} and Maryann Fletcher and Noaris Quintero and Jeanette Baez and Eddy Perez-Then and Solange Soto and Rosangela Mendoza and Raquell Castillo and Guoyan Zhang",
year = "2006",
month = "7",
day = "1",
doi = "10.1089/acm.2006.12.511",
language = "English",
volume = "12",
pages = "511--516",
journal = "Journal of Alternative and Complementary Medicine",
issn = "1075-5535",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

TY - JOUR

T1 - Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1

AU - Shor-Posner, Gail

AU - Hernandez-Reif, Maria

AU - Miguez, Maria Jose

AU - Fletcher, Maryann

AU - Quintero, Noaris

AU - Baez, Jeanette

AU - Perez-Then, Eddy

AU - Soto, Solange

AU - Mendoza, Rosangela

AU - Castillo, Raquell

AU - Zhang, Guoyan

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Purpose: The effectiveness of massage therapy on immune parameters was evaluated in young Dominican HIV+ children without current access to antiretroviral therapies. Methods: Eligible children, who were followed at the Robert Reid Cabral Hospital (San Domingo, Dominican Republic), were randomized to receive either massage treatment or a control/friendly visit twice weekly for 12 weeks. Blood was drawn at baseline and following the 3-month intervention for determinations of CD4, CD8, and CD56 cell counts and percentage, along with activation markers (CD25 and CD69). Results: Despite similar immune parameters at baseline in the two groups, significantly more of the control group exhibited a decline in CD4 cell count (>30%, p = 0.03), postintervention. The decrease was particularly evident in older (5-8 years) children in the control arm, who demonstrated a significant reduction in both CD4 and CD8 cell counts compared to massage-treated older children who remained stable or showed immune improvement. Additionally, a significant increase in CD4+CD25+ cells was observed over the 12-week trial in the massage-treated older children (p = 0.04) but not in the control group. In younger massage-treated children, (2-4 years old), a significant increase in natural killer cells was shown. Conclusion: Together these findings support the role for massage therapy in immune preservation in HIV+ children.

AB - Purpose: The effectiveness of massage therapy on immune parameters was evaluated in young Dominican HIV+ children without current access to antiretroviral therapies. Methods: Eligible children, who were followed at the Robert Reid Cabral Hospital (San Domingo, Dominican Republic), were randomized to receive either massage treatment or a control/friendly visit twice weekly for 12 weeks. Blood was drawn at baseline and following the 3-month intervention for determinations of CD4, CD8, and CD56 cell counts and percentage, along with activation markers (CD25 and CD69). Results: Despite similar immune parameters at baseline in the two groups, significantly more of the control group exhibited a decline in CD4 cell count (>30%, p = 0.03), postintervention. The decrease was particularly evident in older (5-8 years) children in the control arm, who demonstrated a significant reduction in both CD4 and CD8 cell counts compared to massage-treated older children who remained stable or showed immune improvement. Additionally, a significant increase in CD4+CD25+ cells was observed over the 12-week trial in the massage-treated older children (p = 0.04) but not in the control group. In younger massage-treated children, (2-4 years old), a significant increase in natural killer cells was shown. Conclusion: Together these findings support the role for massage therapy in immune preservation in HIV+ children.

UR - http://www.scopus.com/inward/record.url?scp=33750612390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750612390&partnerID=8YFLogxK

U2 - 10.1089/acm.2006.12.511

DO - 10.1089/acm.2006.12.511

M3 - Article

C2 - 16884341

AN - SCOPUS:33750612390

VL - 12

SP - 511

EP - 516

JO - Journal of Alternative and Complementary Medicine

JF - Journal of Alternative and Complementary Medicine

SN - 1075-5535

IS - 6

ER -