Immunotherapy Treatment Patterns and Outcomes Among ALK-Positive Patients With Non–Small-Cell Lung Cancer

Mohammad Jahanzeb; Huamao M. Lin; Xiaoyun Pan; Yu Yin; Pia Baumann; Corey J. Langer

doi:10.1016/j.cllc.2020.08.003

Immunotherapy Treatment Patterns and Outcomes Among ALK-Positive Patients With Non–Small-Cell Lung Cancer

Mohammad Jahanzeb, Huamao M. Lin, Xiaoyun Pan, Yu Yin, Pia Baumann, Corey J. Langer

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The efficacy of immune checkpoint inhibitors (ICI) in ALK-positive non–small-cell lung cancer (NSCLC) is inconclusive as a result of limited data. We conducted a real-world analysis in 83 patients with ALK⁺ advanced NSCLC treated with ICI. The median real-world progression-free survival was 2.34 months from initiation of ICI therapy. The real-world effectiveness of ICI in ALK⁺ NSCLC patients was limited.

Original language	English (US)
Pages (from-to)	49-57
Number of pages	9
Journal	Clinical Lung Cancer
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.cllc.2020.08.003
State	Published - Jan 2021
Externally published	Yes

Keywords

Cancer genomics
Immune checkpoint inhibitor
Next-generation sequencing
Resistance
Targeted therapy

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/j.cllc.2020.08.003

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title = "Immunotherapy Treatment Patterns and Outcomes Among ALK-Positive Patients With Non–Small-Cell Lung Cancer",

abstract = "The efficacy of immune checkpoint inhibitors (ICI) in ALK-positive non–small-cell lung cancer (NSCLC) is inconclusive as a result of limited data. We conducted a real-world analysis in 83 patients with ALK+ advanced NSCLC treated with ICI. The median real-world progression-free survival was 2.34 months from initiation of ICI therapy. The real-world effectiveness of ICI in ALK+ NSCLC patients was limited.",

keywords = "Cancer genomics, Immune checkpoint inhibitor, Next-generation sequencing, Resistance, Targeted therapy",

author = "Mohammad Jahanzeb and Lin, {Huamao M.} and Xiaoyun Pan and Yu Yin and Pia Baumann and Langer, {Corey J.}",

note = "Funding Information: Funded by Millennium Pharmaceuticals Inc , a wholly owned subsidiary of Takeda Pharmaceutical Company Limited . Medical writing support and editorial assitance was provided by Xcenda LLC, and funded by Millenium Pharmaceuticals Inc. Publisher Copyright: {\textcopyright} 2020 The Authors",

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doi = "10.1016/j.cllc.2020.08.003",

language = "English (US)",

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AU - Jahanzeb, Mohammad

AU - Lin, Huamao M.

AU - Pan, Xiaoyun

AU - Yin, Yu

AU - Baumann, Pia

AU - Langer, Corey J.

N1 - Funding Information: Funded by Millennium Pharmaceuticals Inc , a wholly owned subsidiary of Takeda Pharmaceutical Company Limited . Medical writing support and editorial assitance was provided by Xcenda LLC, and funded by Millenium Pharmaceuticals Inc. Publisher Copyright: © 2020 The Authors

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N2 - The efficacy of immune checkpoint inhibitors (ICI) in ALK-positive non–small-cell lung cancer (NSCLC) is inconclusive as a result of limited data. We conducted a real-world analysis in 83 patients with ALK+ advanced NSCLC treated with ICI. The median real-world progression-free survival was 2.34 months from initiation of ICI therapy. The real-world effectiveness of ICI in ALK+ NSCLC patients was limited.

AB - The efficacy of immune checkpoint inhibitors (ICI) in ALK-positive non–small-cell lung cancer (NSCLC) is inconclusive as a result of limited data. We conducted a real-world analysis in 83 patients with ALK+ advanced NSCLC treated with ICI. The median real-world progression-free survival was 2.34 months from initiation of ICI therapy. The real-world effectiveness of ICI in ALK+ NSCLC patients was limited.

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KW - Resistance

KW - Targeted therapy

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Immunotherapy Treatment Patterns and Outcomes Among ALK-Positive Patients With Non–Small-Cell Lung Cancer

Abstract

Keywords

ASJC Scopus subject areas

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