Abstract
One hundred two pregnant women at high risk of infection with the human immunodeficiency virus (62 who were drug abusers and 40 of Haitian origin) were prospectively examined for immunologic changes during and after pregnancy. Among the 63 human immunodeficiency virus-negative women, levels of CD4+ (helper) cells fell to a nadir at 8 weeks before delivery and rose rapidly just before delivery. The level of CD8+ (cytotoxic/suppressor) cells rose slowly from midpregnancy to delivery. Among the 37 human immunodeficiency virus-positive pregnant women, levels of CD4+ cells fell during pregnancy (except for a transient weak increase just before delivery) and did not recover in the postpartum period. Levels of CD8+ cells were consistently higher in human immunodeficiency virus-positive than human immunodeficiency virus-negative women. Post partum the CD8+ cells in human immunodeficiency virus-negative women stabilized at delivery levels, whereas they increased greatly in human immunodeficiency virus-positive women. The loss of CD4+ cells in human immunodeficiency virus-positive women appeared to be faster during pregnancy than in the postpartum period. These data support the hypothesis that pregnancy may accelerate human immunodeficiency virus-induced depletion of CD4+ cells and increase the risk of acquired immunodeficiency syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 1239-1244 |
| Number of pages | 6 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 161 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
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Keywords
- AIDS
- HIV
- immunity
- infants
- pregnancy
- T-lymphocytes
- women
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Immunosuppression in pregnant women infected with human immunodeficiency virus. / Biggar, Robert J.; Pahwa, Savita G; Minkoff, Howard; Mendes, Hermann; Willoughby, Anne; Landesman, Sheldon; Goedert, James J.
In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 5, 01.01.1989, p. 1239-1244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunosuppression in pregnant women infected with human immunodeficiency virus
AU - Biggar, Robert J.
AU - Pahwa, Savita G
AU - Minkoff, Howard
AU - Mendes, Hermann
AU - Willoughby, Anne
AU - Landesman, Sheldon
AU - Goedert, James J.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - One hundred two pregnant women at high risk of infection with the human immunodeficiency virus (62 who were drug abusers and 40 of Haitian origin) were prospectively examined for immunologic changes during and after pregnancy. Among the 63 human immunodeficiency virus-negative women, levels of CD4+ (helper) cells fell to a nadir at 8 weeks before delivery and rose rapidly just before delivery. The level of CD8+ (cytotoxic/suppressor) cells rose slowly from midpregnancy to delivery. Among the 37 human immunodeficiency virus-positive pregnant women, levels of CD4+ cells fell during pregnancy (except for a transient weak increase just before delivery) and did not recover in the postpartum period. Levels of CD8+ cells were consistently higher in human immunodeficiency virus-positive than human immunodeficiency virus-negative women. Post partum the CD8+ cells in human immunodeficiency virus-negative women stabilized at delivery levels, whereas they increased greatly in human immunodeficiency virus-positive women. The loss of CD4+ cells in human immunodeficiency virus-positive women appeared to be faster during pregnancy than in the postpartum period. These data support the hypothesis that pregnancy may accelerate human immunodeficiency virus-induced depletion of CD4+ cells and increase the risk of acquired immunodeficiency syndrome.
AB - One hundred two pregnant women at high risk of infection with the human immunodeficiency virus (62 who were drug abusers and 40 of Haitian origin) were prospectively examined for immunologic changes during and after pregnancy. Among the 63 human immunodeficiency virus-negative women, levels of CD4+ (helper) cells fell to a nadir at 8 weeks before delivery and rose rapidly just before delivery. The level of CD8+ (cytotoxic/suppressor) cells rose slowly from midpregnancy to delivery. Among the 37 human immunodeficiency virus-positive pregnant women, levels of CD4+ cells fell during pregnancy (except for a transient weak increase just before delivery) and did not recover in the postpartum period. Levels of CD8+ cells were consistently higher in human immunodeficiency virus-positive than human immunodeficiency virus-negative women. Post partum the CD8+ cells in human immunodeficiency virus-negative women stabilized at delivery levels, whereas they increased greatly in human immunodeficiency virus-positive women. The loss of CD4+ cells in human immunodeficiency virus-positive women appeared to be faster during pregnancy than in the postpartum period. These data support the hypothesis that pregnancy may accelerate human immunodeficiency virus-induced depletion of CD4+ cells and increase the risk of acquired immunodeficiency syndrome.
KW - AIDS
KW - HIV
KW - immunity
KW - infants
KW - pregnancy
KW - T-lymphocytes
KW - women
UR - http://www.scopus.com/inward/record.url?scp=0024308766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024308766&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(89)90674-1
DO - 10.1016/0002-9378(89)90674-1
M3 - Article
C2 - 2589445
AN - SCOPUS:0024308766
VL - 161
SP - 1239
EP - 1244
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 5
ER -