Immunoregulation on the ocular surface: 2nd cullen symposium

Stephen C. Pflugfelder, Michael E. Stern, Bruce A. Beutler, Alan R. Burns, Margarita Calonge, James Chodosh, M. Reza Dana, Cintia S. De Paiva, Susanne Fleiszig, Linda D. Hazlett, Andrew J. Huang, Dan B. Jones, Yong Jun Liu, Allison M. McDermott, Austin K. Mircheff, Jerry Y. Niederkorn, Victor L Perez Quinones, Eric Perlman, Jim Rosenbaum, Argyrios TheofilopoulusKirk Wilhelmu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A one-day symposium with 20 invited participants was held to review current knowledge regarding immunoregulation in the ocular surface and cornea. The program consisted of 11 lectures on various aspects of ocular and systemic immunoregulation, followed by a group discussion to formulate regulatory pathways. The ocular surface and its secondary lymphoid tissues contain numerous components of the innate and adaptive immune systems, which modulate the immune response to suppress or prevent excessive damaging immune reactions. These include factors that regulate induction of the immune response (afferent loop), as well as effector cells and soluble factors (efferent loop). The ocular surface is an immunologically active mucosal site that contains numerous mechanisms to regulate the immune response to prevent tissue destruction and vision loss.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalOcular Surface
Volume7
Issue number2
StatePublished - Oct 12 2009

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Lymphoid Tissue
Cornea
Immune System
Catalytic Domain

Keywords

  • Antigen-presenting cells
  • Autoimmune reaction
  • Immunoregulatory systems
  • Inflammation
  • Regulatory T cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pflugfelder, S. C., Stern, M. E., Beutler, B. A., Burns, A. R., Calonge, M., Chodosh, J., ... Wilhelmu, K. (2009). Immunoregulation on the ocular surface: 2nd cullen symposium. Ocular Surface, 7(2), 67-77.

Immunoregulation on the ocular surface : 2nd cullen symposium. / Pflugfelder, Stephen C.; Stern, Michael E.; Beutler, Bruce A.; Burns, Alan R.; Calonge, Margarita; Chodosh, James; Dana, M. Reza; De Paiva, Cintia S.; Fleiszig, Susanne; Hazlett, Linda D.; Huang, Andrew J.; Jones, Dan B.; Liu, Yong Jun; McDermott, Allison M.; Mircheff, Austin K.; Niederkorn, Jerry Y.; Perez Quinones, Victor L; Perlman, Eric; Rosenbaum, Jim; Theofilopoulus, Argyrios; Wilhelmu, Kirk.

In: Ocular Surface, Vol. 7, No. 2, 12.10.2009, p. 67-77.

Research output: Contribution to journalArticle

Pflugfelder, SC, Stern, ME, Beutler, BA, Burns, AR, Calonge, M, Chodosh, J, Dana, MR, De Paiva, CS, Fleiszig, S, Hazlett, LD, Huang, AJ, Jones, DB, Liu, YJ, McDermott, AM, Mircheff, AK, Niederkorn, JY, Perez Quinones, VL, Perlman, E, Rosenbaum, J, Theofilopoulus, A & Wilhelmu, K 2009, 'Immunoregulation on the ocular surface: 2nd cullen symposium', Ocular Surface, vol. 7, no. 2, pp. 67-77.
Pflugfelder SC, Stern ME, Beutler BA, Burns AR, Calonge M, Chodosh J et al. Immunoregulation on the ocular surface: 2nd cullen symposium. Ocular Surface. 2009 Oct 12;7(2):67-77.
Pflugfelder, Stephen C. ; Stern, Michael E. ; Beutler, Bruce A. ; Burns, Alan R. ; Calonge, Margarita ; Chodosh, James ; Dana, M. Reza ; De Paiva, Cintia S. ; Fleiszig, Susanne ; Hazlett, Linda D. ; Huang, Andrew J. ; Jones, Dan B. ; Liu, Yong Jun ; McDermott, Allison M. ; Mircheff, Austin K. ; Niederkorn, Jerry Y. ; Perez Quinones, Victor L ; Perlman, Eric ; Rosenbaum, Jim ; Theofilopoulus, Argyrios ; Wilhelmu, Kirk. / Immunoregulation on the ocular surface : 2nd cullen symposium. In: Ocular Surface. 2009 ; Vol. 7, No. 2. pp. 67-77.
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