Immunoregulation in infection caused by mycobacterium tuberculosis: The presence of suppressor monocytes and the alteration of subpopulations of t lymphocytes

Paul Katz, Robert A. Goldstein, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

This study was designed to charaterize qualitative and quantitative alterations, occurring before and during chemoterapy, in the mononuclear cells of patients with infections caused by Mycobacterium tuberculosis. A hemolytic plaque-forming (PFC) assay indicted that the production of antibody to sheep red blood cells by pokeweed mitogen (PWM)-stimulated lymphocytes was suppressed in treated and untreated patients as compared with that in normal adult donors (P < 0.001). The removal of adherent cells from the suspensions of mononuclear cells significantly enhanced the responses to the PFC assay for both the untreated (P <0.01) and treated (P <0.05) patients. Mononuclear cells from patients with tuberculosis, however, did not suppress the PFC responses of allogeneic normal mononuclear cells (P>0.02). Thymus-derived (T) lymphocytes were proportionally reduced in untreated subjects (P < 0.001) but returned to normal levels after 4 to 6 weeks of therapy (P >0.2). Both groups of patients had a consistent reduction in the absolute number of circulating T cells. However, untreated patients had a relative increase in the percentage of TG T(G) (the subpopulation of T cells with receptors for the Fc portion of IgG) (P<0.001) and a concomitant decrese in T(N) cells (the subpopulation with Fc receptors for IgM) (P <0.05). These alterations in the subsets of T cells were reversed after 4 to 6 weeks of therapy.

Original languageEnglish (US)
Pages (from-to)12-21
Number of pages10
JournalJournal of Infectious Diseases
Volume140
Issue number1
DOIs
StatePublished - Jul 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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