Immunoprophylaxis against Klebsiella and Pseudomonas aeruginosa infections

Sam T. Donta, Peter Peduzzi, Alan S. Cross, Jerald Sadoff, Clair Haakenson, Stanley J. Cryz, Carol Kauffman, Suzanne Bradley, Glenn Gafford, Dan Elliston, Thomas R. Beam, Joseph F. John, Bruce Ribner, Robert Cantey, Carolyn H. Welsh, Richard T. Ellison, Edward J. Young, Richard J. Hamill, Howard Leaf, Roland M.H. ScheinMaury Mulligan, Caroline Johnson, Elias Abrutyn, J. Griffiss McLeod, Randa Hamadeh, Arn H. Eliasson, J. Bruce McClain, Gregory P. Melcher, J. William Kelly, W. Russel Byrne, Mark Wallace, Dennis Amundson, Barton Gumpert, David Slagle

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

To determine if passive immunization could decrease the incidence or severity of Klebsiella and Pseudomonas aeruginosa infections, patients admitted to intensive care units of 16 Department of Veterans Affairs and Department of Defense hospitals were randomized to receive either 100 mg/kg intravenous hyperimmune globulin (IVIG), derived from donors immunized with a 24-valent Klebsiella capsular polysaccharide plus an 8-valent P. aeruginosa O-polysaccharide-toxin A conjugate vaccine, or an albumin placebo. The overall incidence and severity of vaccine-specific Klebsiella plus Pseudomonas infections were not significantly different between the groups receiving albumin and IVIG. There was some evidence that IVIG may decrease the incidence (2.7% albumin vs. 1.2% IVIG) and severity (1.0% vs. 0.3%) of vaccine-specific Klebsiella infections, but these reductions were not statistically significant. The trial was stopped because it was statistically unlikely that IVIG would be protective against Pseudomonas infections at the dosage being used. Patients receiving IVIG had more adverse reactions (14.4% vs. 9.2%).

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalJournal of Infectious Diseases
Volume174
Issue number3
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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