Abstract
With a laser nephelometric immunoassay and an empirical formula for the quantitation of central nervous system (CNS) daily IgG synthesis, we studied prospectively a population of 101 individuals divided into four groups: 31 normals, 25 patients with definite multiple sclerosis (DMS), 18 patients with probable or possible multiple sclerosis (PMS), and 27 patients with neurologic disease other than multiple sclerosis (NMS). By the Kruskal-Wallis, test the results of the DMS and PMS patients were significantly different from the normals and NMS patients (P < 0.0003). Considering normals, DMDS, and NMS patients only, the sensitivity of the test was 96%, the specificity was 98%, the positive predictive value was 96%, the negative predictive value was 98%, and the efficiency was 98%. Based on our study data, we applied the predictive value theory to different hypothetical populations (our Neurology Ward, Northeastern U.S., and patients with optic neuritis and chronic progressive myelopathy). In all these situations, the test gave a diagnostic efficiency for multiple sclerosis greater then 95%.
| Original language | English |
|---|---|
| Pages (from-to) | 22-28 |
| Number of pages | 7 |
| Journal | American Journal of Clinical Pathology |
| Volume | 78 |
| Issue number | 1 |
| State | Published - Jan 1 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Immunonephelometric quantitation of central nervous system IgG synthesis in multiple sclerosis. Clinical evaluation using predictive value therapy. / Valenzuela, R.; Mandler, R.; Goren, H.
In: American Journal of Clinical Pathology, Vol. 78, No. 1, 01.01.1982, p. 22-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunonephelometric quantitation of central nervous system IgG synthesis in multiple sclerosis. Clinical evaluation using predictive value therapy
AU - Valenzuela, R.
AU - Mandler, R.
AU - Goren, H.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - With a laser nephelometric immunoassay and an empirical formula for the quantitation of central nervous system (CNS) daily IgG synthesis, we studied prospectively a population of 101 individuals divided into four groups: 31 normals, 25 patients with definite multiple sclerosis (DMS), 18 patients with probable or possible multiple sclerosis (PMS), and 27 patients with neurologic disease other than multiple sclerosis (NMS). By the Kruskal-Wallis, test the results of the DMS and PMS patients were significantly different from the normals and NMS patients (P < 0.0003). Considering normals, DMDS, and NMS patients only, the sensitivity of the test was 96%, the specificity was 98%, the positive predictive value was 96%, the negative predictive value was 98%, and the efficiency was 98%. Based on our study data, we applied the predictive value theory to different hypothetical populations (our Neurology Ward, Northeastern U.S., and patients with optic neuritis and chronic progressive myelopathy). In all these situations, the test gave a diagnostic efficiency for multiple sclerosis greater then 95%.
AB - With a laser nephelometric immunoassay and an empirical formula for the quantitation of central nervous system (CNS) daily IgG synthesis, we studied prospectively a population of 101 individuals divided into four groups: 31 normals, 25 patients with definite multiple sclerosis (DMS), 18 patients with probable or possible multiple sclerosis (PMS), and 27 patients with neurologic disease other than multiple sclerosis (NMS). By the Kruskal-Wallis, test the results of the DMS and PMS patients were significantly different from the normals and NMS patients (P < 0.0003). Considering normals, DMDS, and NMS patients only, the sensitivity of the test was 96%, the specificity was 98%, the positive predictive value was 96%, the negative predictive value was 98%, and the efficiency was 98%. Based on our study data, we applied the predictive value theory to different hypothetical populations (our Neurology Ward, Northeastern U.S., and patients with optic neuritis and chronic progressive myelopathy). In all these situations, the test gave a diagnostic efficiency for multiple sclerosis greater then 95%.
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M3 - Article
VL - 78
SP - 22
EP - 28
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 1
ER -