Immunologically-mediated renal disease in Waldenström's macroglobulinemia

Orlando J. Martelo, Duane R. Schultz, Victor Pardo, Eliseo Perez-Stable

Research output: Contribution to journalArticle

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Abstract

A patient with Waldenström's macroglobulinemia associated with nephrotic syndrome is described. Serum cryoglobulin and rheumatoid factor were absent. Intramembranous electron-dense deposits were demonstrated in kidney biopsy material by electron microscopy. Deposits of immunoglobulin G (IgG), M (IgM) and the third component of complement (C3) were identified hi kidney biopsy tissue by immunofluorescent staining methods. The serum immunoglobulins were characterized by Chromatographic and immunochemical methods and showed a monoclonal IgM-κ, IgG-κ and γ-chain piece of undefined structure. Free κ- and γ-chains were found in the urine. The IgM was not complexed to the IgG or vice versa, but the IgG was in an aggregated form. Although it is not known which immunoglobulin initiated the tissue injury, IgG, IgM and complement deposits probably contributed to the renal dysfunction. The nephrotic syndrome diminished after treatment with chlorambucil and corticosteroids.

Original languageEnglish
Pages (from-to)567-575
Number of pages9
JournalThe American Journal of Medicine
Volume58
Issue number4
DOIs
StatePublished - Jan 1 1975

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Waldenstrom Macroglobulinemia
Immunoglobulin G
Kidney
Nephrotic Syndrome
Immunoglobulins
Immunoglobulin Subunits
Cryoglobulins
Chlorambucil
Biopsy
Myeloma Proteins
Complement C3
Rheumatoid Factor
Serum
Immunoglobulin M
Electron Microscopy
Adrenal Cortex Hormones
Urine
Electrons
Staining and Labeling
Wounds and Injuries

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Immunologically-mediated renal disease in Waldenström's macroglobulinemia. / Martelo, Orlando J.; Schultz, Duane R.; Pardo, Victor; Perez-Stable, Eliseo.

In: The American Journal of Medicine, Vol. 58, No. 4, 01.01.1975, p. 567-575.

Research output: Contribution to journalArticle

Martelo, Orlando J. ; Schultz, Duane R. ; Pardo, Victor ; Perez-Stable, Eliseo. / Immunologically-mediated renal disease in Waldenström's macroglobulinemia. In: The American Journal of Medicine. 1975 ; Vol. 58, No. 4. pp. 567-575.
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