TY - JOUR
T1 - Immunological Role of the Maternal Uterine Microbiome in Pregnancy
T2 - Pregnancies Pathologies and Alterated Microbiota
AU - Bardos, Jonah
AU - Fiorentino, Desiree
AU - Longman, Ryan E.
AU - Paidas, Michael
N1 - Funding Information:
Funding. Funding for the research was provided by the Department of Human Genetics and the Department of Obstetrics and Gynecology at the University of Miami Miller School of Medicine.
PY - 2020/1/8
Y1 - 2020/1/8
N2 - Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo interacts with the maternal endometrium. A perfect relationship between the uterus and the embryo, mediated by a tightly controlled interaction between the embryo and the endometrium, is required for successful implantation. Any factors affecting this communication, such as altered microbiome may lead to poor reproductive outcomes. Current theories suggest that altered microbiota may trigger an inflammatory response in the endometrium that affects the success of embryo implantation, as inflammatory mediators are tightly regulated during the adhesion of the blastocyst to the epithelial endometrial wall. In this review, we will highlight the various microbiome found during the periconceptual period, the microbiomes interaction with immunological responses surrounding the time of implantation, its effect on implantation, placentation and ultimately maternal and neonatal outcomes.
AB - Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo interacts with the maternal endometrium. A perfect relationship between the uterus and the embryo, mediated by a tightly controlled interaction between the embryo and the endometrium, is required for successful implantation. Any factors affecting this communication, such as altered microbiome may lead to poor reproductive outcomes. Current theories suggest that altered microbiota may trigger an inflammatory response in the endometrium that affects the success of embryo implantation, as inflammatory mediators are tightly regulated during the adhesion of the blastocyst to the epithelial endometrial wall. In this review, we will highlight the various microbiome found during the periconceptual period, the microbiomes interaction with immunological responses surrounding the time of implantation, its effect on implantation, placentation and ultimately maternal and neonatal outcomes.
KW - IUGR
KW - early pregnancy immunology
KW - endometrial micorbiome
KW - pre-eclampsia
KW - pregnancy failure
KW - uterine microbiome
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U2 - 10.3389/fimmu.2019.02823
DO - 10.3389/fimmu.2019.02823
M3 - Review article
C2 - 31969875
AN - SCOPUS:85078317539
VL - 10
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 2823
ER -